Results 71 to 80 of about 407,599 (315)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Sedentary Thresholds for Accelerometry-Based Mean Amplitude Deviation and Electromyography Amplitude in 7–11 Years Old Children

Frontiers in Physiology, 2019
We investigated the ability of energy expenditure, movement sensing, and muscle activity to discriminate sedentary and non-sedentary activities in children. Thirty-five 7–11-year-old children participated in the study.
Ying Gao, Eero A. Haapala, Eero A. Haapala, Anssi Vanhala, Arja Sääkslahti, Merja Rantakokko, Arto Laukkanen, Arto J. Pesola, Timo Rantalainen, Taija Finni   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Seats and the City: Sitting as an Idle Act in Ankara Neighbourhoods

PLANARCH - Design and Planning Research
This paper re-evaluates the relationship between walking and idleness in evolving urban contexts, proposing that sitting can be understood as a new form of idleness in response to the accelerating speed of urban routines. Drawing on the established urban
Sezin Sarıca, Bengisu Derebaşı
doaj   +1 more source

Independent and combined associations of sugar-sweetened beverage consumption, TV viewing, and physical activity with severe depressive symptoms among 59,402 adults [PDF]

Brazilian Journal of Psychiatry
Objective: Our aim was to analyze the association between sugar-sweetened beverage consumption and depressive symptoms, as well as the extent to which TV viewing and physical activity moderate this association. Methods: We used cross-sectional data from
André O. Werneck, Felipe B. Schuch, Brendon Stubbs, Adewale L. Oyeyemi, Célia L. Szwarcwald, Davy Vancampfort, Danilo R. Silva   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Sedentary Behavior and Health Consequences: A Systematic Scoping Review of Prospective and Longitudinal Studies in Japan

Journal of Epidemiology
Objectives: This scoping review summarizes and evaluates evidence from Japan on prospective relationships of sedentary behavior (too much sitting, as distinct from too little physical activity) with health outcomes, forming the basis for Japan’s new ...
Ai Shibata, Kaori Ishii, Neville Owen, Koichiro Oka   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Comparison of the Right-to-left Shunt Test by Transcranial Doppler Based on the Addition of Blood and Patient Posture

Korean Journal of Clinical Laboratory Science
Using transcranial doppler ultrasonography (TCD) to measure the presence or absence of abnormalities in patent foramen ovale (PFO) is more effective than transesophageal echocardiography (TEE) because it is simple, inexpensive, and non-invasive. Thus, it
Kun-Woo KANG, Eui-Jeong LEE, Hyun-Kyung LEE, Eun-Son LEE, Yang-Hee LIM   +4 more
doaj   +1 more source

Office Work Chairs – Research of Deformations and Comfort Index [PDF]

Drvna Industrija, 2010
Construction of the seat and back of the office chair, as an actual object of the human working environment, is important in its final design since these are the elements that are in a direct and close contact with human body. The sitting position is the
Zoran Vlaović, Ivica Grbac, Danijela Domljan, Andrej Bublić
doaj