Results 91 to 100 of about 286,272 (317)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Nude woman sitting crossing legs and filing a goblet from a pitcher

, 2021
Unknown
openalex   +2 more sources

School of Nursing, OAUTHC, Ile- Ife admission form-2023/2024,is out now ☎{07068583206} ADMIN{0706-858-3206} The current approved entry requirement is five (5) O'level credit passes in Mathematics, English Language, Physics, Chemistry and Biology at not more than two (2) sittings from any of the following: West African Examination Council (WAEC), National Examination Council (NECO)

, 2023
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openalex   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Design and Evaluation of Stand-to-Sit and Sit-to-Stand Control Protocols for a HIP–Knee–Ankle–Foot Prosthesis with a Motorized Hip Joint

Bioengineering
Background: Sitting and standing with conventional hip–knee–ankle–foot (HKAF) prostheses are demanding tasks for hip disarticulation (HD) amputees due to the passive nature of current prosthetic hip joints that cannot assist with moment generation.
Farshad Golshan, Natalie Baddour, Hossein Gholizadeh, David Nielen, Edward D. Lemaire   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Two nude women turning around and sitting on the ground

, 2021
Unknown
openalex   +2 more sources

Comparison of the Right-to-left Shunt Test by Transcranial Doppler Based on the Addition of Blood and Patient Posture

Korean Journal of Clinical Laboratory Science
Using transcranial doppler ultrasonography (TCD) to measure the presence or absence of abnormalities in patent foramen ovale (PFO) is more effective than transesophageal echocardiography (TEE) because it is simple, inexpensive, and non-invasive. Thus, it
Kun-Woo KANG, Eui-Jeong LEE, Hyun-Kyung LEE, Eun-Son LEE, Yang-Hee LIM   +4 more
doaj   +1 more source

Office Work Chairs – Research of Deformations and Comfort Index [PDF]

Drvna Industrija, 2010
Construction of the seat and back of the office chair, as an actual object of the human working environment, is important in its final design since these are the elements that are in a direct and close contact with human body. The sitting position is the
Zoran Vlaović, Ivica Grbac, Danijela Domljan, Andrej Bublić
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source