Results 51 to 60 of about 447,435 (164)

Immunobiological Correlates of SIV Vaccine Vectors and Macaque Tropism

Vaccine Research, 2019
The field of HIV vaccines received a “boost” with around 30% protection obtained in the RV144 randomized, double-blind, efficacy trial in Thailand. Currently, 560 clinical trials in HIV vaccine development are registered as complete and results are ...
Joseph Antony
doaj  

Fenfluramine in Rett syndrome: A multidimensional clinical study

Epilepsia Open, EarlyView.
Abstract Objective Rett syndrome (RTT) is a severe neurodevelopmental disorder frequently associated with drug‐resistant epilepsy, autonomic dysfunction, respiratory abnormalities, sleep disturbances, and behavioral impairment. Fenfluramine has shown efficacy in developmental and epileptic encephalopathies and may provide broader therapeutic benefits ...
Elena Gonzalez‐Alguacil, Nuria Lamagrande Casanova, Manuel Luján Bonete, David Mansilla Lozano, Juan José García Peñas, María Ballará Petitbó, Rocío Trincado Lamuño, Verónica Cantarín‐Extremera, Raquel Díaz Conejo, César Rodríguez Sánchez, Adrián García Ron, Víctor Soto Insuga   +11 more
wiley   +1 more source

Neuroinflammatory Profiling in SIV-Infected Chinese-Origin Rhesus Macaques on Antiretroviral Therapy

Viruses, 2022
The central nervous system (CNS) HIV reservoir is an obstacle to achieving an HIV cure. The basal ganglia harbor a higher frequency of SIV than other brain regions in the SIV-infected rhesus macaques of Chinese-origin (chRMs) even on suppressive ...
Antonio Solis-Leal, Summer Siddiqui, Fei Wu, Mahesh Mohan, Wenhui Hu, Lara A. Doyle-Meyers, Jason P. Dufour, Binhua Ling   +7 more
doaj   +1 more source

The molecular evolution of the most dangerous emerging virus infections

Annals of Mechnikov's Institute, 2020
In this paper we reviewed what is known about the emerging viruses, the hosts that they originate in, and the molecular events that drive their emergence.
N Popov, T Kolotova
doaj  

Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel [PDF]

, 2008
The rectum is particularly vulnerable to HIV transmission having only a single protective layer of columnar epithelium overlying tissue rich in activated lymphoid cells; thus, unprotected anal intercourse in both women and men carries a higher risk of ...
Peter Anton, Herrera, Carolina, Sally Sharpe, Anton, Peter, McGowan Ian, Kashuba Angela, Robin Shattock, Herrera Carolina, Rezk, N, Angela Kashuba, Herrera, C, Ian McGowan, Alethea Cope, Shattock Robin, Cope Alethea, McGowan, Ian, Shattock, R, Ham Claire, Cranage, M, Cope, A, Sharpe, Sally, Berry Neil, Heeney, J, Mike Dennis, Ham, C, Cranage Martin, Kashuba, A, McGowan, I, Claire Ham, Sharpe Sally, Heeney, Jonathan, Dennis, M, Berry, N, Kashuba, Angela, Anton Peter, Neil Berry, Cranage, Martin, Berry, Neil, Sharpe, S, Martin Cranage, Naser Rezk, Anton, P, Rezk, Naser, Dennis, Mike, Cope, Alethea, Ham, Claire, Rezk Naser, Heeney Jonathan, Carolina Herrera, Jonathan Heeney, Dennis Mike, Shattock, Robin   +51 more
core   +2 more sources

Residual Limb Hyperhidrosis in Prosthetic Users: First Prospective Pilot of Topical Antiperspirant Treatment

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Residual limb hyperhidrosis (RLH) is a frequent and debilitating condition among lower‐limb prosthetic users. Although aluminium chloride is recommended first‐line for focal hyperhidrosis, its efficacy in RLH has not previously been evaluated in prospective studies.
Jette Schack, Kim Magnus Advocaat Sandberg Endre, Andrew Ritchie, Harald Steen   +3 more
wiley   +1 more source

Predicting Statistical Signatures of Collective Emission in Disordered Color Center Ensembles

Laser &Photonics Reviews, EarlyView.
We present an efficient simulation framework for modeling collective emission in disordered ensembles of quantum emitters. The low computational complexity enables large‐scale Monte Carlo simulations. Applied to SiV−${\rm SiV}^{-}$ clusters, it predicts thresholded superradiant bursts set by emitter number and quantum efficiency, as well as interaction‐
Qingyi Zhou, Wenxin Wu, Maryam Zahedian, Zongfu Yu, Jennifer T. Choy   +4 more
wiley   +1 more source

Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus Macaques

Viruses, 2022
HIV vaccine mediated efficacy, using an expanded live attenuated recombinant varicella virus-vectored SIV rSVV-SIVgag/env vaccine prime with adjuvanted SIV-Env and SIV-Gag protein boosts, was evaluated in a female rhesus macaques (RM) model against ...
Bapi Pahar, Wayne Gray, Marissa Fahlberg, Brooke Grasperge, Meredith Hunter, Arpita Das, Christopher Mabee, Pyone Pyone Aye, Faith Schiro, Krystle Hensley, Aneeka Ratnayake, Kelly Goff, Celia LaBranche, Xiaoying Shen, Georgia D. Tomaras, C. Todd DeMarco, David Montefiori, Patricia Kissinger, Preston A. Marx, Vicki Traina-Dorge   +19 more
doaj   +1 more source

The Physical, Emotional, and Autonomous Anthropomorphism of Service Chatbots

Psychology &Marketing, EarlyView.
ABSTRACT Prior research on chatbot anthropomorphism has often treated it as a unidimensional construct, producing inconsistent findings regarding how human‐like design cues shape user responses. This study conceptualizes anthropomorphism as a multidimensional higher‐order perception comprising three distinct forms of anthropomorphic attribution ...
Yangjuan Hu, Fulya Acikgoz, Shubin Yu
wiley   +1 more source

Construction optimization and functional applications of fluorescent nanodiamonds

Responsive Materials, EarlyView.
This review summarizes synthesis, surface modification and optical properties of fluorescent nanodiamonds. Their advances in quantum sensing, single‐photon emission and biomedicine are discussed, and existing challenges and future directions are presented.
Yunpeng Yang, Sen Zhang, Chao Chen, Wensi Yang, Zuanquan Chen, Rui Fan, Linlin Liu, Benjian Liu, Kang Liu, Zhibo Zhang, Bing Dai, Jiaqi Zhu   +11 more
wiley   +1 more source