Results 61 to 70 of about 447,435 (164)
Journal of Medical Internet ResearchBackgroundOlder adults are more vulnerable to severe consequences caused by seasonal influenza. Although seasonal influenza vaccination (SIV) is effective and free vaccines are available, the SIV uptake rate remained inadequate ...
Zixin Wang +7 more
doaj +1 more source
Smart Molecules, EarlyView.AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin +10 more
wiley +1 more source
Naturally Occurring ZCCHC3 Variants Modulate Antiretroviral Activity in Cynomolgus Macaques
Microbiology and Immunology, EarlyView.ABSTRACT Many mammalian cells restrict viral replication by utilizing various host restriction factors. We recently demonstrated that CCHC‐type zinc‐finger‐containing protein 3 (ZCCHC3) suppresses human immunodeficiency virus type 1 (HIV‐1) replication through multiple mechanisms.
Jacob Fadipe +3 more
wiley +1 more source
Pre‐Seasonal Treatment With Recombinant Carrier‐Based Birch Vaccine Improves Birch Pollen Allergy
Allergy, EarlyView.We conducted a two stage SCIT trial with GNR‐127 containing a recombinant fusion protein consisting of Bet v 1 and Mal d 1‐derived peptides fused to PreS from HBV. Stage 1 identified two safe maximum tolerated doses (40 μg and 80 μg). In the following Stage 2, five preseasonal injections were well tolerated, induced dose‐dependent allergen‐specific IgG,
Musa R. Khaitov +43 more
wiley +1 more source
Seasonal influenza self-vaccination behaviours and attitudes among nurses in Southeastern France
Human Vaccines & Immunotherapeutics, 2019 Background: Despite seasonal influenza vaccination (SIV) being recommended to healthcare professionals to protect themselves and their patients, uptake is low, especially among nurses.
Rose Wilson +6 more
doaj +1 more source
Child &Family Social Work, EarlyView.ABSTRACT Honour‐based violence (HBV) is a serious social problem with significant health and social consequences for affected children. Despite growing policy attention, little is known about how child protection services address HBV in practice. This study examines how child protection investigations categorized as HBV are handled by a specialized ...
Stina Lindegren, Siv‐Britt Björktomta
wiley +1 more source
International Journal of Nanomedicine, 2019 Taofeng Du,1,2,* Guang Zhu,1,2,* Xiaoping Wu,1,2 Junyang Fang,1,2 En-Min Zhou1,2 1Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi, People’s Republic of China ...
Du T, Zhu G, Wu X, Fang J, Zhou EM
doaj
Fujita Medical Journal, 2020 Objective: Sivelestat sodium hydrate (Siv) is expected to be an effective therapy for acute respiratory distress syndrome, although its mechanism of action is not understood.
Yasuyoshi Kurimoto +9 more
doaj +1 more source
Relics, writing, and devotion in early medieval Chelles
Early Medieval Europe, EarlyView.The discovery in 1983 of a collection of relics with their medieval identificatory tags in the parish church of Chelles opened new avenues for research on devotional and writing practices in this Frankish royal foundation. This is the first systematic study of the corpus of relic labels that accompanied these sacred objects, particularly of the subset ...
Ana de Oliveira Dias
wiley +1 more source
Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
The FEBS Journal, EarlyView.EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source