Results 91 to 100 of about 43,308,262 (294)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Birth Order Matters: The Effect of Family Size and Birth Order on Educational Attainment [PDF]

We use unique retrospective family background data from the 2003 wave of the British Household Panel Survey to explore the degree to which family size and birth order affect a child’s subsequent educational attainment. Theory suggests a trade off between
Hiau Joo Kee, Alison Booth
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Secular Trends of Sizes at Birth in Japanese Healthy Infants Born between 1962 and 1988

, 2004
Body sizes at birth are important clinical indicators widely used for evaluation of prenatal growth. Japan had significant socioeconomic improvement around the 1960s, and these environmental changes may influence physiologically prenatal growth ...
Oishi, Kazuyo, Aoyagi, Kiyoshi, Takemoto, Tai-Ichiro, Kusano, Yosuke, Takamura, Noboru, Abe, Yasuyo, Tahara, Yasuaki, Honda, Sumihisa, Moji, Kazuhiko   +8 more
core  

Genetic evaluation for milk production, the weights of kids at birth and weaning for dairy Damascus goats [PDF]

Iraqi Journal of Veterinary Sciences, 2014
The Objective of this research, study the performance on Shami goats of the studied traits.which include milk production kg, and litter size weight at birth and weaning kg were 270.24±67.24, 8.42±0.53 and 23.98±2.94, respectively. The value of the litter
K. Fattal, Kh. Elnajjar, M. Roukbi1
doaj  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Offspring birth weight, gestational age and maternal characteristics in relation to glucose status at age 53 years: evidence from a national birth cohort. [PDF]

, 2008
AIMS: We investigated pathways linking offspring birth weight to maternal diabetes risk in later life by taking into account a range of prospective early-life and adult maternal factors.
Mishra, G. D., Hardy, R, Black, S., Hardy, R., Lawlor, D, Wadsworth, M., Wadsworth, M, Lawlor, D A., Kuh, D, Lawlor, DA, Smith, G. D., Kuh, D., Black, S, Mishra, GD, Davey Smith, G, Okell, L, Okell, L.   +16 more
core   +1 more source

Determinants of Low Birth Weight in Malawi: Bayesian Geo-Additive Modelling.

PLoS ONE, 2015
Studies on factors of low birth weight in Malawi have neglected the flexible approach of using smooth functions for some covariates in models. Such flexible approach reveals detailed relationship of covariates with the response.
Alfred Ngwira, Christopher C Stanley
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study [PDF]

, 2001
Objective To examine the association between birth weight and cognitive function in the normal population.Design A longitudinal, population based, birth cohort study.Participants 3900 males and females born in 1946.Main outcome measures Cognitive ...
Richards, M, Hardy, R, Wadsworth, MEJ, Kuh, D   +3 more
core