Results 131 to 140 of about 2,901 (160)

Interleukin‐40 in Systemic Sclerosis: A Treatment‐Sensitive Marker of Immune Modulation Rather Than Disease Activity

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Interleukin‐40 (IL‐40) is a recently identified cytokine primarily produced by activated B cells and implicated in immune regulation across several autoimmune diseases. Although B cell–driven immune dysregulation plays a central role in systemic sclerosis (SSc), the circulating behavior and clinical relevance of IL‐40 in this disease remain ...
İbrahim Vasi, Emin Ümit Bağrıaçık, Rıza Can Kardaş, Nihan Örüklü, Melek Yaman, Derya Yıldırım, Burcugül Kaya, Rahime Duran, İbrahim Karaduman, İbrahim Yahya Çakır, Hamit Küçük, Berna Göker, Abdulsamet Erden, Mehmet Akif Öztürk   +13 more
wiley   +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6584-6594, August 2026.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas, Baerbel Rotthaeuser, Niels Porksen, Pascale Labard, My‐Liên Nguyên‐Pascal, Mathieu Coudert, Baptiste Berthou, Marie Baccara‐Dinet, Gabor Boka, Mark Peakman, Felix Reschke, Michael J. Haller   +11 more
wiley   +1 more source

Examining the Role of Artificial Intelligence in Assessment: A Comparative Study of ChatGPT and Educator‐Generated Multiple‐Choice Questions in a Dental Exam

European Journal of Dental Education, Volume 30, Issue 3, Page 881-895, August 2026.
ABSTRACT Aim To compare the item difficulty and discriminative index of multiple‐choice questions (MCQs) generated by ChatGPT with those created by dental educators, based on the performance of dental students in a real exam setting. Materials and Methods A total of 40 MCQs—20 generated by ChatGPT 4.0 and 20 by dental educators—were developed based on ...
Nezaket Ezgi Özer, Yusuf Balcı, Gaye Bölükbaşı, Betul İlhan, Pelin Güneri   +4 more
wiley   +1 more source

Beyond Venous Inflammation: Vessel Wall Imaging of Intracranial Arteries in Neuro‐Behçet's Syndrome

European Journal of Neurology, Volume 33, Issue 8, August 2026.
ABSTRACT Background Neuro‐Behçet syndrome (NBS) is a heterogeneous inflammatory disorder in which venous involvement is well recognized, while intracranial arterial pathology remains insufficiently characterized. Conventional luminal imaging methods are limited in detecting early or isolated arterial wall abnormalities.
Esra Kochan Kizilkilic, Bora Korkmazer, Nursena Erener, Ahmet Kursat Karaman, Abdullah Arcan, Serdar Arslan, Aksel Siva, Emire Seyahi, Ugur Uygunoglu, Osman Kizilkilic   +9 more
wiley   +1 more source

Pellagra in Contemporary Clinical Practice (2000–2023): A Systematic Review

International Journal of Dermatology, Volume 65, Issue 8, Page 1590-1599, August 2026.
This systematic review (2000–2023) of 1212 cases highlights pellagra's evolving etiology. While primary dietary deficiency (85%) persists in humanitarian crises, secondary forms from alcohol misuse (9.6%), isoniazid (14.3% of drug‐related cases), and malabsorption are rising.
Noureddine Litaiem, Karama Sboui, Faten Zeglaoui   +2 more
wiley   +1 more source

High‐Dimensional Immune Profiling Identifies Circulating NKT‐Like Cells Associated With Severity Outcome in Acute Pancreatitis at Disease Onset

Immunology, Volume 178, Issue 4, Page 685-703, August 2026.
High‐dimensional spectral cytometry of peripheral blood mononuclear cells at hospital admission revealed that acute pancreatitis patients who subsequently developed moderately‐to‐severe disease exhibited a specific reduction of circulating CD2 + CD8dim NKT‐like cells, which appear to acquire an altered cytotoxic‐like phenotype upon IL‐15 stimulation ...
Carolina González de Castro, Mª. Lourdes Ruiz Rebollo, Paloma Cal‐Sabater, Elisa Arribas‐Rodríguez, Álvaro Martín‐Muñoz, Alejandro Gonzalez del Hierro, Marina Perez Mazzali, Jessica Matesanz‐Isabel, Hugo Gonzalo‐Benito, Sara Cuesta‐Sancho, David Bernardo   +10 more
wiley   +1 more source

Age‐Associated B Cells: Origins, Regulation, and Tissue‐Specific Pathogenic Contributions in Autoimmune, Metabolic, and Neurological Diseases

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Age‐associated B cells (ABCs) are a distinct B cell population characterized by coexpression of T‐bet and CD11c. First described in aged female mice and autoimmune‐prone strains, ABCs are now recognized to be associated with multiple human autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis,
Kira Rubtsova
wiley   +1 more source

Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk.
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do   +2 more
wiley   +1 more source

Single‐Cell RNA Sequencing Revealed the Role of Interferon‐Gamma Related Genes in Primary Sjögren's Syndrome

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder. Dysregulated interferon‐gamma (IFN‐γ) signalling is implicated in pSS pathogenesis, yet the underlying mechanisms remain elusive. This study aimed to identify key IFN‐γ‐associated diagnostic genes and delineate their roles in immune dysregulation using peripheral blood ...
Lei Shi, Tian‐chi Wei, Jing Zhang
wiley   +1 more source

Clinical application of a modified platelet desialylation test for mechanistic characterization of platelet transfusion refractoriness

Transfusion, Volume 66, Issue 8, Page 1520-1535, August 2026.
Abstract Background Platelet transfusion refractoriness (PTR) is a major challenge in transfusion medicine and may result from both immune and non‐immune mechanisms. Although alloantibodies are well‐established contributors, Fc‐independent pathways such as platelet desialylation have emerged as alternative mechanisms of clearance.
Karen Ziza, Thamy Silva, Mateus Domentino, Marina Conrado, João Oliveira, Elyse Moritz, Akemi Chiba, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Langhi Dante, Carla Dinardo   +11 more
wiley   +1 more source