Results 71 to 80 of about 37,519 (224)

An antigen-driven B-cell response within the salivary glands of patients with Sjögren’s syndrome [PDF]

, 2002
Infection with a bacterium or virus induces the production of antibodies, specialised protein molecules that bind to and eliminate the microorganism.
Berek, C., Stott, D.I.
core  

Genome‐Wide DNA Methylation Patterns in Naive CD4+ T Cells From Patients With Primary Sjögren's Syndrome [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106121/1/art38264 ...
Altorok, Asou, Bave, Bird, Browning, Bruniquel, Clark, Cobb, Coit, Delaleu, Dennis, Emamian, Fava, Fava, Fox, Fu, Gatumu, Gottenberg, Hediger, Hjelmervik, Hu, Huang, Hughes, Jeffries, Kassan, Kassan, Kundu, Mavragani, Morinobu, Murayama, Nikolov, Okuda, Pertovaara, Relton, Rennert, Shen, Shen, Sun, Thabet, Vitali, Ware, Weissman   +41 more
core   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Acquisition of N-Glycosylation Sites in Immunoglobulin Heavy Chain Genes During Local Expansion in Parotid Salivary Glands of Primary Sjogren Patients [PDF]

, 2018
Previous studies revealed high incidence of acquired N-glycosylation sites acquired N-glycosylation sites in RNA transcripts encoding immunoglobulin heavy variable region (IGHV) 3 genes from parotid glands of primary Sjogren's syndrome (pSS) patients. In
Bende, Richard J., Bootsma, Hendrika, Bos, Nicolaas A., de Vries, Niek, Doorenspleet, Marieke E., Kroese, Frans G. M., Spijkervet, Fred K. L., Visser, Annie, Vissink, Arjan   +8 more
core   +2 more sources

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Modulation of c-Jun NH2-Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome [PDF]

, 2011
Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH2 terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) present in the sera of patients ...
Borda, Enri Santiago, Passafaro, Daniela, Reina, Silvia, Sterin Borda, Leonor   +3 more
core   +1 more source

Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation

Annals of Neurology, EarlyView.
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko, Gargi Banerjee, Dermot Mallon, Kitti Thiankhaw, Rupert Oliver, Victoria Harvey, Gareth Ambler, Michael Zandi, Hans Rolf Jäger, David J. Werring   +9 more
wiley   +1 more source

Quantitative Assessment of Salivary Gland Parenchymal Vascularization Using Power Doppler Ultrasound and Superb Microvascular Imaging: A Potential Tool in the Diagnosis of Sjögren"s Syndrome

Balkan Medical Journal, 2020
Background: Primary Sjögren’s syndrome is a chronic inflammatory autoimmune disease. Minor salivary gland biopsy is the gold standard for the diagnosis of primary Sjögren’s syndrome.
Fethi Emre Ustabaşıoğlu, Selçuk Korkmaz, Ufuk İlgen, Serdar Solak, Osman Kula, Sezin Turan, Hakan Emmüngil   +6 more
doaj   +1 more source

Sjögren’s syndrome-associated microRNAs in CD14+ monocytes unveils targeted TGFβ signaling [PDF]

, 2016
SjS-associated miRNA expression levels are positively associated in CD14+ monocytes. Linear regression analyses were used to define associations between miRNAs in HC (circle, n = 17), SLE (triangle, n = 17), and RA (diamond, n = 18) patient groups ...
Adrienne E. G. Williams, Annie L. Chan, Carol M. Stewart, Kevin Choi, Michael R. Bubb, Seunghee Cha, Westley H. Reeves, Yun Jong Lee   +7 more
core   +4 more sources