Genetic Evidence Implicating Gut Microbiota and Circulating Cytokines in Sjögren's Syndrome. [PDF]
Cai Y +5 more
europepmc +1 more source
Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics
ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu +3 more
wiley +1 more source
CSF Anti-Sjögren's Syndrome Antigen A Antibodies and Low Glucose Levels in Sjögren's Syndrome-Associated Aseptic Meningitis: A Case Report. [PDF]
Ueno T +4 more
europepmc +1 more source
This study investigated the bidirectional relationship and shared mechanisms between sarcopenia and osteoporosis using data from the UK Biobank. Our findings indicated that the two conditions may act as reciprocal risk factors, with multiple potential biomarkers mediating the muscle‐bone relationship and suggested possible shared signals between the ...
Siqi Xu +10 more
wiley +1 more source
Causal associations between Sjögren's syndrome and subtypes of endometrial cancer. [PDF]
Zhu Y, Wu Q, Hu L, Wang L.
europepmc +1 more source
ABSTRACT Cutaneous crystal‐storing histiocytosis (CSH) is an extremely rare histopathologic finding of histiocytes accumulating crystals of immunoglobulin or paraproteins, often associated with lymphoplasmacytic malignancies. It commonly presents in a wide age range of both female and male adults with a history of a lymphoproliferative disorder ...
Ashton Arlen +3 more
wiley +1 more source
Esophageal melanosis in a patient with systemic lupus erythematosus and Sjögren's syndrome: A case report. [PDF]
Maldonado-Gutiérrez C +5 more
europepmc +1 more source
Unsupervised Flow Cytometry Reveals a Constant Shift Towards Activated CD4+ T Cell Subsets in APECED
APECED is caused by mutations of AIRE that impair negative selection in the human thymus. Using our optimized unsupervised workflow, we reveal that APECED patients show increased activation of T cells and alterations to their Treg pool as well as a novel T cell population not found among healthy controls.
Joonatan Mattila +6 more
wiley +1 more source
Acute Ischemic Stroke as the Initial Presentation of Primary Sjögren's Syndrome: A Case Report. [PDF]
Pakal YK, Gade SN, Dharap NP.
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source

