Results 101 to 110 of about 2,563,441 (411)

Dietary fibre may mitigate sarcopenia risk:Findings from the NU-AGE cohort of older european adults [PDF]

, 2020
Sarcopenia is characterised by a progressive loss of skeletal muscle mass and physical function as well as related metabolic disturbances. While fibre-rich diets can influence metabolic health outcomes, the impact on skeletal muscle mass and function is ...
Battista, Giuseppe, Bazzocchi, Alberto, Berendsen, Agnes, de Groot, Lisette C.P.G.M., Fairweather-Tait, Susan, Feskens, Edith J.M., Franceschi, Claudio, Januszko, Olga, Jennings, Amy, Kadi, Fawzi, Montiel-Rojas, Diego, Nicoletti, Claudio, Nilsson, Andreas, Pietruszka, Barbara, Santoro, Aurelia   +14 more
core   +4 more sources

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont, Adam Deardorff, Murad Nawaz, Andrew A. Voss, Mark M. Rich   +4 more
wiley   +1 more source

Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science

Skeletal Muscle, 2012
Se-Jin Lee was elected member to the National Academy of Sciences on 28 April 2012. Dr Lee is responsible for the discovery of myostatin, a critical regulator of skeletal muscle mass and function.
Glass David J, Spiegelman Bruce M
doaj   +1 more source

Sarcospan Regulates Cardiac Isoproterenol Response and Prevents Duchenne Muscular Dystrophy-Associated Cardiomyopathy. [PDF]

, 2015
BackgroundDuchenne muscular dystrophy is a fatal cardiac and skeletal muscle disease resulting from mutations in the dystrophin gene. We have previously demonstrated that a dystrophin-associated protein, sarcospan (SSPN), ameliorated Duchenne muscular ...
Crosbie-Watson, Rachelle H, Jordan, Maria C, Marshall, Jamie L, Nguyen, Reginald T, Parvatiyar, Michelle S, Richardson, Vanitra A, Roos, Kenneth P   +6 more
core   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

PPARδ regulates satellite cell proliferation and skeletal muscle regeneration

Skeletal Muscle, 2011
Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptors that play important roles in development and energy metabolism. Whereas PPARδ has been shown to regulate mitochondrial biosynthesis and slow-muscle fiber types, its ...
Angione Alison R, Jiang Chunhui, Pan Dongning, Wang Yong-Xu, Kuang Shihuan   +4 more
doaj   +1 more source

Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers

Skeletal Muscle, 2023
Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane.
Dongwoo Hahn, Joseph D. Quick, Brian R. Thompson, Adelyn Crabtree, Benjamin J. Hackel, Frank S. Bates, Joseph M. Metzger   +6 more
doaj   +1 more source

Hyperglycemia induces skeletal muscle atrophy via a WWP1/KLF15 axis.

JCI Insight, 2019
Diabetes mellitus is associated with various disorders of the locomotor system including the decline in mass and function of skeletal muscle. The mechanism underlying this association has remained ambiguous, however. We now show that the abundance of the
Y. Hirata, K. Nomura, Yoko Senga, Y. Okada, Kenta Kobayashi, S. Okamoto, Y. Minokoshi, M. Imamura, S. Takeda, T. Hosooka, W. Ogawa   +10 more
semanticscholar   +1 more source

Vitamin D, a modulator of musculoskeletal health in chronic kidney disease [PDF]

, 2017
The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD ...
Jordi Bover, Juan J. Carrero, null null, Pablo Molina, Pablo Ureña Torres, Philippe Chauveau, Sandro Mazzaferro   +6 more
core   +2 more sources

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source