Results 131 to 140 of about 2,563,441 (411)

Effects of Exercise and Aging on Skeletal Muscle.

Cold Spring Harbor Perspectives in Medicine, 2018
A substantial loss of muscle mass and strength (sarcopenia), a decreased regenerative capacity, and a compromised physical performance are hallmarks of aging skeletal muscle.
G. Distéfano, B. Goodpaster
semanticscholar   +1 more source

11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle [PDF]

, 2009
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown.
Morgan, S. A., Sherlock, M., Gathercole, L.L, Lavery, Gareth G., Lenaghan, C., Bujalska, I.J, Laber, D., Yu, A., Convey, G., Mayers, R., Hegyi, K., Sethi, J. K., Stewart, P M, Smith, D. M., Tomlinson, J W   +14 more
core   +4 more sources

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

Advanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo   +12 more
wiley   +1 more source

Nitric oxide availability is increased in contracting skeletal muscle from aged mice, but does not differentially decrease muscle superoxide [PDF]

, 2014
Reactive oxygen and nitrogen species have been implicated in the loss of skeletal muscle mass and function that occurs during aging. Nitric oxide (NO) and superoxide are generated by skeletal muscle and where these are generated in proximity their ...
A. McArdle, Ali, Balon, Beckman, Braga, Broome, Chang, Close, Cobley, Cortese-Krott, Dubuisson, Erusalimsky, Grozdanovic, Hirschfield, Kobzik, Kojima, Lau, Leiter, Lexell, M.J. Jackson, McConell, Melov, Morley, Muller, Murrant, Nyberg, Palomero, Palomero, Pattwell, Pearson, Porter, Pulliam, Pye, Radi, Reid, Richmonds, Ropelle, Ryall, Sakellariou, Sakellariou, Samengo, Sasaki, Sastre, Sawada, Shefer, Sohal, Song, T. Pearson, Tidball, Trujillo, Vasilaki, Vasilaki, Vasilaki, Vasilaki, Wang, Young   +55 more
core   +2 more sources

Cell‐Delivering Injectable Hydrogels with Tunable Microporous Structures Improve Therapeutic Efficacy for Volumetric Muscle Loss

Advanced Functional Materials, EarlyView.
The study presents an injectable hydrogel with tunable microporosity to improve mesenchymal stem cell delivery for volumetric muscle loss treatment. Mesenchymal stem cells encapsulated in porous hydrogels significantly promote the spreading, proliferation, and cytokine secretion of mesenchymal stem cells.
Hana Yasue, Tetsushi Taguchi, Taka‐Aki Asoh, Akihiro Nishiguchi   +3 more
wiley   +1 more source

Author Correction: Long-term voluntary running prevents the onset of symptomatic Friedreich’s ataxia in mice

Scientific Reports, 2021
Henan Zhao, Bevan M. Lewellen, Rebecca J. Wilson, Di Cui, Joshua C. Drake, Mei Zhang, Zhen Yan   +6 more
doaj   +1 more source

TAK-1/p38/nNFκB signaling inhibits myoblast differentiation by increasing levels of Activin A

Skeletal Muscle, 2012
Background Skeletal-muscle differentiation is required for the regeneration of myofibers after injury. The differentiation capacity of satellite cells is impaired in settings of old age, which is at least one factor in the onset of sarcopenia, the age ...
Trendelenburg Anne, Meyer Angelika, Jacobi Carsten, Feige Jerome N, Glass David J   +4 more
doaj   +1 more source

Engineering human pluripotent stem cells into a functional skeletal muscle tissue

Nature Communications, 2018
The generation of functional skeletal muscle tissues from human pluripotent stem cells (hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) via transient overexpression of Pax7 in paraxial mesoderm cells differentiated
Lingjun Rao, Ying Qian, A. Khodabukus, T. Ribar, N. Bursac   +4 more
semanticscholar   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Transgenic overexpression of γ-cytoplasmic actin protects against eccentric contraction-induced force loss in mdx mice

Skeletal Muscle, 2011
Background γ-cytoplasmic (γ-cyto) actin levels are elevated in dystrophin-deficient mdx mouse skeletal muscle. The purpose of this study was to determine whether further elevation of γ-cyto actin levels improve or exacerbate the dystrophic phenotype of ...
Baltgalvis Kristen A, Jaeger Michele A, Fitzsimons Daniel P, Thayer Stanley A, Lowe Dawn A, Ervasti James M   +5 more
doaj   +1 more source