Results 211 to 220 of about 965,762 (355)

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

open access: yesAdvanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang   +10 more
wiley   +1 more source

Impact of Incretin-Based Therapy on Skeletal Muscle Health. [PDF]

open access: yesMedicina (Kaunas)
Koceva A, Janež A, Jensterle M.
europepmc   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

open access: yesAdvanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang   +4 more
wiley   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

open access: yesAdvanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang   +16 more
wiley   +1 more source

Brown adipose tissue and skeletal muscle coordinately contribute to thermogenesis in mice. [PDF]

open access: yesElife
Izumi-Mishima Y   +11 more
europepmc   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

open access: yesAdvanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu   +17 more
wiley   +1 more source

ACSS2 involved in acetyl-CoA synthesis regulates skeletal muscle function. [PDF]

open access: yesFEBS Lett
Gunasekaran M   +6 more
europepmc   +1 more source

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