Results 31 to 40 of about 39,942 (265)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Doubt and dogmatism in Cicero’s Academica

open access: yesArchai: Revista de Estudos sobre as Origens do Pensamento Ocidental, 2019
The objective is to show the peculiar way in which Cicero’s philosophical thinking is original and distances itself from the main representatives of the New Academy: the Roman thinker does not practice epoche, nor does he assign any special role to it in
Alexandre Skvirsky
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

On Dependency between Wishes and Perception

open access: yesДискурс, 2021
Introduction. Empirical studies of recent years convincingly show that the character of sensory perception can be influenced by non-cognitive mental states of the agent, such as her desires.
A. I. Ponomarev, K. G. Frolov
doaj   +1 more source

Skeptical Thoughts Concerning Explanationism and Skepticism

open access: yesSymposion, 2014
According to the explanationist, we can rely on inference to best explanation to justifiably believe familiar skeptical hypotheses are false. On this view, commonsense beliefs about the existence and character of familiar, medium-sized dry goods provides the best explanation of our evidence and so justifies our belief that we're not brains-in-vats ...
openaire   +3 more sources

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

Metaphor, skepticism, understanding Metaphor, skepticism, understanding

open access: yesIlha do Desterro, 2010
<p align="left">This paper examines the idea that metaphor is a basic cognitive tool from a Wittgensteinian point of view. One specific aspect of Wittgenstein&rsquo;s legacy is explored, namely his account of verbal understanding.
Helena Martins
doaj  

Artificial Intelligence–Based Online Symptom Assessment Tools for Systemic Lupus Erythematosus Diagnosis: Patient Perspectives

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this article is to identify perceptions of patients with systemic lupus erythematosus (SLE) regarding artificial intelligence (AI)–based online symptom assessment tools, and the potential of these tools to address diagnostic barriers.
Olivia A. Stein   +7 more
wiley   +1 more source

Factors Associated with Fibromyalgia Diagnosis amongst People Meeting Criteria: Results from UK Biobank

open access: yesArthritis Care &Research, Accepted Article.
Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification. This study
Sung‐A Kim   +2 more
wiley   +1 more source

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