Results 71 to 80 of about 253,185 (280)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Pix3D: Dataset and Methods for Single-Image 3D Shape Modeling
, 2018 We study 3D shape modeling from a single image and make contributions to it in three aspects. First, we present Pix3D, a large-scale benchmark of diverse image-shape pairs with pixel-level 2D-3D alignment.
Freeman, William T. +7 more
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
It’s GIrls’ Day! What sketch maps show about girls’ spatial knowledge [PDF]
, 2014 Ponencias, comunicaciones y pósters presentados en el 17th AGILE Conference on Geographic Information Science "Connecting a Digital Europe through Location and Place", celebrado en la Universitat Jaume I del 3 al 6 de junio de 2014.This paper describes
Anacta, Vanessa Joy A. +1 more
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Development of the small community according to its interpretation on maps [PDF]
, 2016 Predmetom tejto bakalárskej práce je pozorovanie vývoja obce Stará Turá podľa jej zobrazenia na mapách. Skúmanými podkladmi sú dostupné historické a súčasné kartografické diela stredných mierok, ktoré zobrazujú územie mesta a jeho okolie.
Demková, Michaela
core
Configurations, and parallelograms associated to centers of mass
, 2006 The purpose of this article is to \begin{enumerate} \item define $M(t,k)$ the $t$-fold center of mass arrangement for $k$ points in the plane, \item give elementary properties of $M(t,k)$ and \item give consequences concerning the space $M(2,k ...
Cohen, F. R., Kamiyama, Y.
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A Cube Analytical Mining Framework for Stream Data
Dianxin kexue, 2014 Stream data has been one of the most significant data format recently. OLAM（online analytical mining） operation could provide multi-level data views for analysts.
Canghong Jin +3 more
doaj +2 more sources