Results 211 to 220 of about 41,798 (261)

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

open access: yesAdvanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su   +14 more
wiley   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

open access: yesAdvanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

open access: yesAdvanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng   +13 more
wiley   +1 more source
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The modality of skew t-distribution

Statistical Papers, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Testing for sub-models of the skew t-distribution

Statistical Methods & Applications, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Thomas J. DiCiccio, Anna Clara Monti
openaire   +1 more source

Multivariate extended skew-t distributions and related families

METRON, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Arellano-Valle, Reinaldo B.   +1 more
openaire   +2 more sources

Robust mixture modeling using the skew t distribution

Statistics and Computing, 2007
A finite mixture model using the Student's t distribution has been recognized as a robust extension of normal mixtures. Recently, a mixture of skew normal distributions has been found to be effective in the treatment of heterogeneous data involving asymmetric behaviors across subclasses.
Tsung-I Lin, Jack C. Lee, Wan J. Hsieh
openaire   +1 more source

Skew t distributions via the sinh-arcsinh transformation

TEST, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rosco, J. F.   +2 more
openaire   +1 more source

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