Results 31 to 40 of about 17,511,424 (267)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Student recruitment survey 2021: The market bounces back! [PDF]

, 2021
This report sets out the findings of the 2021 ISE Student Recruitment Survey. This is a detailed survey comprising of 69 questions. The survey ran during September 2021 and received 177 responses from large student employers, covering 45,312 ...
Institute of Student Employers
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The First Negative Moment of Skew-tand Generalized Student'st-Distributions in the Principal Value Sense [PDF]

Journal of Applied Mathematics, 2013
The (Cauchy) principal value is a method for assigning values to certain improper integrals which would otherwise be undefined. Using the principal value sense, this study derives an explicit expression of the first negative moment of skew-tand generalized Student'st-distributions for practical applications.
openaire   +4 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

GAS or GARCH: A comparison of density and VaR forecasts in Turkish FX and stock markets

Istanbul Business Research
This paper compares the renowned GARCH model with a novel one, the Generalized Autoregressive Score (GAS) model in terms of forecasting performance. Considering the gap in the literature, this study focuses on the Turkish stock and FX markets.
Ali Ulvi Özgül
doaj   +1 more source

The Basel 2.5 capital regulatory framework and the COVID-19 crisis: evidence from the ethical investment market [PDF]

PSU Research Review
Purpose – This research aims to evaluate the accuracy of several Value-at-Risk (VaR) approaches for determining the Minimum Capital Requirement (MCR) for Islamic stock markets during the pandemic health crisis. Design/methodology/approach – This research
Wassim Ben Ayed, Rim Ben Hassen
doaj   +1 more source

A Two-Parameter Inverted Exponentiated Skewed Student-T Distribution: Theory and Application

International Journal of Development Mathematics (IJDM)
In this study, a new two-parameter generalization of the skew-t distribution called the Inverted Exponentiated Skew t distribution, has been proposed. Some properties of the model like order statistics, entropy, asymptotic behavior, moments, characteristic function, and quantile function were derived.
Danjuma Idi, Danjuma Jibasen, Abraham Okolo, Emmanuel Torsen   +3 more
openaire   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

A Comparative APARCH Volatility Study of International Markets

Economies
This paper compares the daily return volatility by four leading international indices: JSE Top 40, FTSE 100, Nikkei 225 and S&P/ASX 200. The return series are modelled in ARMA process, where ARMA(1,3) values are taken for JSE Top 40 and S&P/ASX 200, ARMA(
Fhulufhedzani Justice Madega, Thinawanga Hangwani Tshisikhawe, Thakhani Ravele, Caston Sigauke   +3 more
doaj   +1 more source