Results 31 to 40 of about 318 (202)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Forces Affecting Timber Skidding
Croatian Journal of Forest Engineering, 2009 The research was carried out on the strip road where longitudinal slopes were determined by the leveling method as well as individual distances of the strip road of uniform slope.
Željko Tomašić +3 more
doaj
Journal of Forest Science, 2018 This study was conducted in order to estimate the economic life of two models of rubber-tired skidders, namely Timberjack 450C and HSM 904, in Iranian Caspian forests. The total annual costs and average cumulative cost of skidders were calculated by life-
Mohammad HEJAZIAN +2 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Croatian Journal of Forest Engineering, 2013 This paper describes an indirect method of determining exposure to vibration of skidder driv- ers using the Fleet Manager System. The hand-arm exposure of workers to vibration is expressed as energy equivalent A(8), which is determined by the procedure ...
Dubravko Horvat +3 more
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Croatian Journal of Forest Engineering, 2017 Harvest traffic with heavy equipment causes damage to forest soils. Whereas increased soil damage has been reported with increasing harvest equipment traffic and on increasing slope gradients, it is unclear how much soil damage is caused by different ...
Ramin Naghdi +5 more
doaj
IMAGE-BASED NAVIGATION OF FOREST HARVESTERS [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2012 The focus of this paper the use of multi-image matching techniques in forestry applications. Background of the study is the problem of navigating heavy harvesters through skidder trails on their way to harvesting individual trees.
M. Schulze
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source