Results 51 to 60 of about 318 (202)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Time consumption and productivity of skidding Silver fir (Abies alba Mill.) round wood in reduced accessibility conditions: a case study in windthrow salvage logging form Romanian Carpathians [PDF]

Annals of Forest Research, 2013
Natural calamities (especially windthrows) may generate difficultwork conditions in timber harvesting operations. When associated with the reduced accessibility conditions, the work conditions become even harder.
Stelian Alexandru Borz, Florin Dinulică, Marcian Bîrda, Gheorghe Ignea, Valentina Doina Ciobanu, Bogdan Popa   +5 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

ANÁLISE TÉCNICA E DE CUSTO DO FELLER BUNCHER E SKIDDER NA COLHEITA DE MADEIRA EM DIFERENTES PRODUTIVIDADES DO POVOAMENTO

Ciência Florestal, 2015
The objective of this study was to do a technical and costs analysis of a feller buncher and skidder in module harvesting Pinus taeda L. plantations in stands with different productivities.
André Leonardo Nasser Pereira, Eduardo da Silva Lopes, Andrea Nogueira Dias   +2 more
doaj  

Modernization of the powertrain of the tracked skidder

Agrarian Scientific Journal
A way to increase the maneuverability of the chassis of a forest tracked vehicle through the use of on-board reverse gearboxes is proposed. As an example, one of the possible kinematic schemes of such a gearbox is considered. The principles of composing kinematics equations and determining the values of internal gear ratios characterizing the planetary
Roman Yurievich Dobretsov, Alexander Pavlovich Chajkin, Sergey Aleksandrovich Voinash, Ramil Ravilievich Zagidullin, Viktoriia Aleksandrovna Sokolova, Sergey Aleksandrovich Korol   +5 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Modelling of Downhill Timber Skidding: Bigger Load – Bigger Slope

Croatian Journal of Forest Engineering, 2016
Skidder mobility during timber extraction is defined by: 1) basic dimensional features of the vehicle, 2) ability to overcome obstacles during movement, 3) traction performance and 4) environmental soundness.
Andreja Đuka, Tomislav Poršinsky, Tibor Pentek, Dubravko Horvat   +3 more
doaj  

Ergonomic evaluation of the musculoskeletal disorders risk by QEC method in forest harvesting [PDF]

مجله جنگل ایران, 2019
Today, skeletal musculoskeletal disorders are one of the most important occupational health issues and have a high prevalence in almost all occupations, and preventing it involves evaluating and modifying working conditions.
Zahra Arman, Mehrdad Nikooy, Mahmood Heidari, Baris Majnonian   +3 more
doaj  

Optimisation of a clam bunk skidder from the emission production point of view

Research in Agricultural Engineering, 2012
This article presents a proposal of a simple mathematical model for minimisation of the production of extraneous substances as a function of the rate of operation performance of a production system.
A. Janeček, R. Adamovský
doaj   +1 more source