From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Disrupting Motor Cortical Regional Activity during Motor Sequence Skill Training Impairs Human Motor Visuomotor Skill Acquisition and Learning That Is Not Sequence-Specific. [PDF]
eNeuroGutierrez I +4 more
europepmc +1 more source
Skills in Flux - Challenges in AI-based Skills Management and Skills Profiles.
The changing world of work, driven by automation and digital tech-nologies, requires a workforce that continuously adapts its skills in order to be competitive and employable. This dynamic environment has fueled the demand for advanced skills management, with artificial intelligence (AI) playing a critical role in measuring and supporting individual ...
Leonie Rebecca Freise +2 more
openaire +2 more sources
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Directed Sector and Skill-Specific Technological Change: The Development of Wages for the High and Low Skilled [PDF]
This paper presents a dynamic two sector, two skill groups model of endogenous skill and sector specific technological change. The sectors refer to a "high-tech” and a "low-tech” sector of an economy.
Juergen Antony
core
Early skill learning is shaped by the offline emergence of expert synergies. [PDF]
Curr BiolKistler W +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Skill-based technology adoption: firm-level evidence from Brazil and India [PDF]
This paper provides the first firm-level econometric evidence on the skill-bias of ICT in developing countries using a unique new dataset of manufacturing firms in Brazil and India. I use detailed information on firms' adoption of ICT and the educational
Rupert Harrison
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source