Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations. [PDF]
Neurorehabil Neural RepairWolpaw JR +5 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Employee-AI collaboration empowers mentor networks to enhance employee creativity: a knowledge-management perspective. [PDF]
Front PsycholLi M, Yu Y, Yin J.
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Program LIFT: protocol for a pilot feasibility factorial randomised controlled trial of digital single-session interventions to address self-harm and suicidal ideation in Australian community-based adolescents. [PDF]
BMJ OpenHatoum AH +6 more
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Fundamental Motor Skills and Physical Activity: Short-Term but Not Sustained Associations Between Improved Locomotor Skills and Preschoolers' Physical Activity Following a Motor Skill Intervention. [PDF]
Pediatr Exerc SciPalmer SA +3 more
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Need To Train Professional Ethics Skills in Students in Physical Education and Sports
ACROSSThe approach to ethics in the field of physical education and sports is related to education and school, being very important at every national and transnational level. The different decision-makers in the differently organized countries of the European
Natalia PUTIN
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