Results 101 to 110 of about 6,156,020 (403)

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

Communications Biology, 2020
Fibroblasts are an essential cell population for human skin architecture and function. While fibroblast heterogeneity is well established, this phenomenon has not been analyzed systematically yet.
Llorenç Solé-Boldo, G. Raddatz, S. Schütz, Jan-Philipp Mallm, K. Rippe, A. Lonsdorf, Manuel Rodríguez-Paredes, F. Lyko   +7 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Development and evaluation of a rapid diagnostic method for Sporothrix globosa in Asia using quantitative real-time PCR

BMC Infectious Diseases
Background Sporotrichosis is a chronic granulomatous infection of the skin and subcutaneous tissue that can affect any organ through lymphatic spread. The prevalence of sporotrichosis infections is increasing and its treatment is challenging as there are
Hanqing Geng, Lele Sun, Chuan Wang, Yong Zhang, Shufen Wang, Yanru Cheng, Fangfang Bao, Hong Liu, Furen Zhang   +8 more
doaj   +1 more source

A Real-World, Non-interventional Indian Study Evaluating Intensive Plant-Based Butter Moisturizing Cream in Psoriasis

Dermatology and Therapy, 2019
Introduction Psoriasis is estimated to affect 0.44–2.8% of the Indian population. Moisturizers are a key adjuvant psoriasis treatment strategy, but data regarding their effectiveness, safety and compliance pattern in an Indian context are lacking. Hence,
Hemangi Rajiv Jerajani, Jayakar Thomas, Alka Gupta, Gurram Narasimha Rao Netha, Ranju Chawla, Rashid Shaikh, Ravindra Babu, Irene Williams, Prajakta Talathi, Suyog C. Mehta, Rajan Mittal, Shivani Acharya, Sujeet N. Charugulla   +12 more
doaj   +1 more source

Influence of PWM on the proximity loss in permanent magnet brushless AC machines [PDF]

, 2008
The winding copper loss can be significantly increased due to skin and proximity eddy current effects. The skin and proximity losses due to fundamental frequency current has been investigated in literature, but the influence of PWM on the skin and ...
Bremner, J., Deodhar, R., Iwasaki, S., Liu, Y., Pride, A., Zhu, Z.Q.   +5 more
core   +1 more source

SKIN GRAFTING

Dermatologic Clinics, 2000
No longer an option of last resort, skin grafting has become a technique that is routinely and sometimes preferentially considered as skin replacement for burns, chronic ulcers, and skin defects after cutaneous surgical procedures. When selected as the best alternative for wound closure, autologous skin grafts are commonly considered the gold standard.
I C, Valencia, A F, Falabella, W H, Eaglstein   +2 more
openaire   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A prospective, double‐blinded, randomized head‐to‐head clinical trial of topical adapinoid (oleyl adapalenate) versus retinol

Skin Health and Disease
Background Retinoids, such as retinol, are widely investigated and utilized in skin care products as a treatment for photoaging but their use is limited by tolerability. Adapinoid (oleyl adapalenate, OA) is a novel third generation retinoid that is a pro‐
Nhi Nguyen, Nasima Afzal, Mildred Min, Nabeel Ahmad, Laila Afzal, Waqas Burney, Cindy J. Chambers, Raja K. Sivamani   +7 more
doaj   +1 more source

Untargeted metabolomics yields insight into extramammary Paget’s disease mechanisms

Frontiers in Oncology
BackgroundExtramammary Paget’s disease (EMPD) is a rare cutaneous malignancy, commonly affecting the external genitalia and perianal area of the elderly with unclear pathogenesis.
Long Jiang, Long Jiang, Xiaoxiang Xu, Xiaoxiang Xu, Guorong Yan, Guorong Yan, Guorong Yan, Yuhao Wu, Yuhao Wu, Yuhao Wu, Ningyuan Xi, Ningyuan Xi, Yongxian Lai, Yongxian Lai, Guolong Zhang, Guolong Zhang, Guolong Zhang, Yeqiang Liu, Yeqiang Liu   +18 more
doaj   +1 more source

Fair comparison of skin detection approaches on publicly available datasets

, 2020
Skin detection is the process of discriminating skin and non-skin regions in a digital image and it is widely used in several applications ranging from hand gesture analysis to track body parts and face detection.
Lumini, Alessandra, Nanni, Loris
core   +1 more source