Results 51 to 60 of about 4,250,920 (342)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris

Nature Communications
Pityriasis rubra pilaris (PRP) is an inflammatory papulosquamous dermatosis, characterized by hyperkeratotic follicular papules and erythematous desquamative plaques. The precise pathogenic mechanism underlying PRP remains incompletely understood. Herein,
Peidian Shi, Wenjie Chen, Xinxing Lyu, Zhenzhen Wang, Wenchao Li, Fengming Jia, Chunzhi Zheng, Tingting Liu, Chuan Wang, Yuan Zhang, Zihao Mi, Yonghu Sun, Xuechao Chen, Shengli Chen, Guizhi Zhou, Yongxia Liu, Yingjie Lin, Fuxiang Bai, Qing Sun, Monday O. Ogese, Qiang Yu, Jianjun Liu, Hong Liu, Furen Zhang   +23 more
doaj   +1 more source

Consensus Recommendations for Treatment Strategies in Indians Using Botulinum Toxin and Hyaluronic Acid Fillers

Plastic and Reconstructive Surgery, Global Open, 2017
Background:. Indians constitute one of the largest population groups in the world. Facial anthropometry, morphology, and age-related changes in Indians differ from those of other ethnic groups, necessitating a good understanding of their facial structure
Krishan Mohan Kapoor, MCh, DNB, Vandana Chatrath, MD, MSc, Chytra Anand, DD, MSc, Rashmi Shetty, MD, Chiranjiv Chhabra, MD, Kuldeep Singh, MCh, Maya Vedamurthy, MD, Jamuna Pai, MBBS, Bindu Sthalekar, MD, Rekha Sheth, MD, on behalf of the Indian Facial Aesthetics Expert Group   +10 more
doaj   +1 more source

Impact of COVID-19 pandemic on the epidemiology of STDs in China: based on the GM (1,1) model

BMC Infectious Diseases, 2022
Background COVID-19 and Sexually Transmitted Diseases (STDs) are two very important diseases. However, relevant researches about how COVID-19 pandemic has impacted on the epidemiological trend of STDs are limited in China. This study aimed to analyze the
Jingmin Yan, Yanbo Li, Pingyu Zhou
doaj   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Impact of chromophores on colour appearance in a computational skin model [PDF]

, 2020
Early diagnosis of skin cancer offers the patient more favorable treatment options. Color fidelity of skin images is a major concern for dermatologists as adoption of digital dermatoscopes is increasing rapidly. Accurate color depiction of the lesion and
Bakic, Predrag R., De Paepe, Lode, Kimpe, Tom, Maidment, Andrew D. A., Philips, Wilfried, Platisa, Ljiljana, Vasudev, Varun   +6 more
core   +4 more sources

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Histopathological Features of Nevus Sebaceous and Superimposed Skin Tumors

Journal of Skin Cancer
Conclusion: Our study revealed that malignant tumors were more common than benign lesions in patients with NS. Benign neoplasms were more frequent in women. Malignant neoplasms were detected in patients aged more than 25 years.
Paridokht Karimian, Naz Zargar Javaheri, Kaveh Gharaei Nejad, Hojat Eftekhari, Elahe Rafiei, Rana Rafiei   +5 more
doaj   +1 more source

T cell co-stimulatory and co-inhibitory pathways in atopic dermatitis

Frontiers in Immunology, 2023
The use of immune checkpoint inhibitors (ICIs) targeting the T cell inhibitory pathways has revolutionized cancer treatment. However, ICIs might induce progressive atopic dermatitis (AD) by affecting T cell reactivation.
Chunjiao Zheng, Yuling Shi, Ying Zou
doaj   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source