Results 71 to 80 of about 495,232 (306)

Evaluation of skin absorption of drugs from topical and transdermal formulations

Brazilian Journal of Pharmaceutical Sciences
The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs.
André Luís Morais Ruela, Aline Gravinez Perissinato, Mônica Esselin de Sousa Lino, Paula Silva Mudrik, Gislaine Ribeiro Pereira   +4 more
doaj   +1 more source

Metabolism of skin-absorbed resveratrol into its glucuronized form in mouse skin. [PDF]

PLoS ONE, 2014
Resveratrol (RESV) is a plant polyphenol, which is thought to have beneficial metabolic effects in laboratory animals as well as in humans. Following oral administration, RESV is immediately catabolized, resulting in low bioavailability.
Itsuo Murakami, Romanas Chaleckis, Tomáš Pluskal, Ken Ito, Kousuke Hori, Masahiro Ebe, Mitsuhiro Yanagida, Hiroshi Kondoh   +7 more
doaj   +1 more source

Two new type surface polaritons excited into nanoholes in metal films [PDF]

, 2010
First, we argue that the smooth metal-air interface should be regarded as a distinct dielectric medium, the skin of the metal. The existence of this metal skin leads to theoretical explanation of experimental data on the excitation of electromagnetic ...
Minasyan, V. N., Samoilov, V. N.
core   +2 more sources

A two-phase two-layer model for transdermal drug delivery and percutaneous absorption

, 2014
One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery).
de Monte, Filippo, Pontrelli, Giuseppe
core   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Solute–Vehicle–Skin Interactions and Their Contribution to Pharmacokinetics of Skin Delivery

Pharmaceutics
Human skin provides an effective route of delivery for selected drugs. Topical penetration of molecules is largely attributed to passive diffusion, and the degree of penetration can be represented by in silico, in vitro, and ex vivo models.
Pronalis Tapfumaneyi, Khanh Phan, Yicheng Huang, Kewaree Sodsri, Sarika Namjoshi, Howard Maibach, Yousuf Mohammed   +6 more
doaj   +1 more source

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo [PDF]

, 2020
Significance: Detection and characterization of circulating tumor cells (CTCs), a key determinant of metastasis, are critical for determining risk of disease progression, understanding metastatic pathways, and facilitating early clinical intervention.
Cornelius, Lynn A., Hai, Pengfei, Li, Yang, Qu, Yuan, Shmuylovich, Leonid, Wang, Lihong V., Zhu, Liren   +6 more
core   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Impact of Skin Decontamination Wipe Solutions on the Percutaneous Absorption of Polycyclic Aromatic Hydrocarbons

Toxics
Firefighter occupational exposures were categorized as a class 1 (known) carcinogen by the International Agency for Research on Cancer in 2022. As a result, firefighters have become heavily focused on identifying effective and easy to implement ...
Chandler Probert, R. Bryan Ormond, Ronald E. Baynes   +2 more
doaj   +1 more source

Graphene-based photonic crystal

, 2010
A novel type of photonic crystal formed by embedding a periodic array of constituent stacks of alternating graphene and dielectric discs into a background dielectric medium is proposed.
Anton A. Kolesnikov, Berman, Berman, Berman, Castro Neto, Chigrin, Das Sarma, Eldada, Falkovsky, Falkovsky, Falkovsky, Gusynin, Gusynin, Joannopoulos, Joannopoulos, John, Katsnelson, Kechedzhi, Kuzmiak, Landau, Lozovik, Luk'yanchuk, McGurn, Nair, Nomura, Novoselov, Novoselov, Oleg L. Berman, Roman Ya. Kezerashvili, Taflove, Takeda, Takeda, Takeda, Tőke, Ulrich, Vladimir S. Boyko, Yablonovitch, Yurii E. Lozovik, Zhang, Zhang   +39 more
core   +1 more source