A Study of the Skin Absorption of Ethylbenzene in Man [PDF]
Occupational and Environmental Medicine, 1967 The absorption of ethylbenzene through the skin of the hand and the forearm in men was investigated experimentally. Both the absorption of liquid ethylbenzene and the absorption from aqueous solutions were studied. The rate of absorption of liquid ethylbenzene was 22 to 33 mg./cm. 2 /hr, and the rates from aqueous solutions were 118 and 215 μg./cm.
T, Dutkiewicz, H, Tyras
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New cationic nanovesicular systems containing lysine-based surfactants for topical administration: Toxicity assessment using representative skin cell lines [PDF]
, 2013 Many strategies for treating diseases require the delivery of drugs into the cell cytoplasm following internalization within endosomal vesicles. Thus, compounds triggered by low pH to disrupt membranes and release endosomal contents into the cytosol are ...
Vinardell, M. Pilar +11 more
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Toxics, 2022 The cosmetic industry has flourished in recent years. Accordingly, the safety of cosmetic ingredients is increasing. Bromochlorophene (BCP) is a commonly used cosmetic preservative.
Yong-Jae Lee +4 more
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Assessment of the potential skin irritation of lysine-derivative anionic surfactants using mouse fibroblast and human keratinocytes as an alternative to animal testing [PDF]
, 2004 Purpose. The aim of this study was to identify new surfactants with low skin irritant properties for use in pharmaceutical and cosmetic formulations, employing cell culture as an alternative method to in vivo testing.
Vinardell, M. Pilar +7 more
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Human Skin Permeation of Ethoxy- and Propoxypropanol Commonly Found in Water-Based Products
ToxicsSome propylene glycol ethers (PGEs) have been associated with reproductive toxicity. Ethoxypropanol (PGEE) and propoxypropanol (PGPE) are two common PGEs found in many commercial products.
Hélène P. De Luca +4 more
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A two-dimensional mathematical model of percutaneous drug absorption
, 2004 Background When a drug is applied on the skin surface, the concentration of the drug accumulated in the skin and the amount of the drug eliminated into the blood vessel depend on the value of a parameter, r.
K Kubota +8 more
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Modeling the sampling volume for the skin blood oxygenation measurements [PDF]
, 2001 The absolute quantified measurement of haemoglobin skin blood saturation from collected reflectance spectra of the skin is complicated by the fact that the blood content of tissues can vary both in the spatial distribution and in the amount.
Meglinski, I. V., Matcher, S. J.
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Effect of continuous phase drug concentration, evaporation and partitioning on transdermal drug permeation kinetics with lipophilic vehicles [PDF]
, 2008 In this work the dependence of transdermal drug permeation kinetics on continuous phase drug concentration, partitioning between formulation phases, partitioning between stratum corneum and continuous oil phase and evaporation of volatile formulation ...
Reiser, Miriam Regina Luise
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Analysis of skin tissues spatial fluorescence distribution by the Monte Carlo simulation [PDF]
, 2003 A novel Monte Carlo technique of simulation of spatial fluorescence distribution within the human skin is presented. The computational model of skin takes into account the spatial distribution of fluorophores, which would arise due to the structure of
Churmakov, D. Y. +3 more
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Test No. 427: Skin Absorption: In Vivo Method [electronic resource] /
, 2004 The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline, allows the
Organisation for Economic Co-operation and Development.
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