Guidance on dermal absorption [PDF]
EFSA Journal, 2017 This guidance on the assessment of dermal absorption has been developed to assist notifiers, users of test facilities and Member State authorities on critical aspects related to the setting of dermal absorption values to be used in risk assessments of ...
European Food Safety Authority (EFSA) +11 more
doaj +9 more sources
Effect of Application Amounts on In Vitro Dermal Absorption Test Using Caffeine and Testosterone [PDF]
Pharmaceutics, 2021 Dermal absorption of chemicals is a key factor in risk assessment. This study investigated the effects of different amounts of application on dermal absorption and suggested an appropriate application dose for proper dermal absorption.
Jueng-Eun Im +5 more
doaj +4 more sources
Pharmacokinetics and the Dermal Absorption of Bromochlorophene, a Cosmetic Preservative Ingredient, in Rats [PDF]
Toxics, 2022 The cosmetic industry has flourished in recent years. Accordingly, the safety of cosmetic ingredients is increasing. Bromochlorophene (BCP) is a commonly used cosmetic preservative.
Yong-Jae Lee +4 more
doaj +2 more sources
Analytical Method Development and Dermal Absorption of Pyrogallol, a Hair Dye Ingredient [PDF]
Toxics, 2022 Pyrogallol is an ingredient in hair dye. Its concentration in hair dye is managed at less than 2.0% in Korea. There have been no reports on the dermal absorption rate of pyrogallol.
Yu-Jin Kim +5 more
doaj +2 more sources
Race, pigmentation, and the human skin barrier—considerations for dermal absorption studies [PDF]
Frontiers in Toxicology, 2023 A functional human skin barrier is critical in limiting harmful exposure to environmental agents and regulating the absorption of intentionally applied topical drug and cosmetic products.
Alec T. Salminen +2 more
doaj +2 more sources
Development and Evaluation of an In Silico Dermal Absorption Model Relevant for Children [PDF]
Pharmaceutics, 2022 The higher skin surface area to body weight ratio in children and the prematurity of skin in neonates may lead to higher chemical exposure as compared to adults.
Yejin Esther Yun +3 more
doaj +2 more sources
Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture [PDF]
Pharmaceutics, 2022 Arnica tincture is a traditional herbal medicine used to treat blunt injuries, e.g., bruises and squeezes. In addition, a potential new use in the treatment of cutaneous leishmaniasis is currently under investigation.
Franziska M. Jürgens +3 more
doaj +2 more sources
In Vitro Human Dermal Absorption Studies on Pesticides in Complex Mixtures: Investigation of Guidance Criteria and Possible Impact Parameters [PDF]
ToxicsPesticides must not pose unacceptable risks to human health, so risk assessments are conducted before products are authorised. Dermal exposure is often the main route of intake, so estimating realistic and trustworthy dermal absorption values is crucial ...
Christina Pieper +4 more
doaj +2 more sources
Analytical Method Development and Dermal Absorption of 4-Amino-3-Nitrophenol (4A3NP), a Hair Dye Ingredient under the Oxidative or Non-Oxidative Condition [PDF]
ToxicsThe chemical 4-amino-3-nitrophenol (4A3NP) is classified as an amino nitrophenol and is primarily utilized as an ingredient in hair dye colorants. In Korea and Europe, it is exclusively used in non-oxidative or oxidative hair dye formulations, with ...
Hyang Yeon Kim +4 more
doaj +2 more sources
Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel [PDF]
Pharmaceutics, 2016 Effective topical therapy of cutaneous fungal diseases requires the delivery of the active agent to the target site in adequate concentrations to produce a pharmacological effect and inhibit the growth of the pathogen.
Mahima Manian +3 more
doaj +2 more sources