Multi-phase multi-layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin. [PDF]
CPT Pharmacometrics Syst Pharmacol, 2022 Physiologically‐based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption, distribution, metabolism, excretion characteristics, formulation attributes, and trial design or ...
Patel N +14 more
europepmc +2 more sources
Retrospective analysis of dermal absorption triple pack data. [PDF]
ALTEX, 2021 Dermal toxicity is driven by the ability of a substance to penetrate the skin. The “triple pack” approach, which combines in vivo rat, in vitro rat, and in vitro human data, is used to calculate an estimated human dermal absorption factor (DAF).
Allen DG +4 more
europepmc +2 more sources
Enhancing Dermal Absorption of Cosmeceuticals: Innovations and Techniques for Targeted Skin Delivery. [PDF]
J Cosmet DermatolAs beauty consumption upgrades and skincare concepts evolve toward science‐backed efficacy, the field of cosmetology has put forward higher requirements for the dermal absorption efficiency of efficacious products.
Peng Y, Yue L, Cong Y.
europepmc +2 more sources
Modeling Temperature-Dependent Dermal Absorption and Clearance for Transdermal and Topical Drug Applications. [PDF]
AAPS J, 2020 A computational model was developed to better understand the impact of elevated skin temperatures on transdermal drug delivery and dermal clearance.
LaCount TD +7 more
europepmc +2 more sources
Dermal Absorption of Sesquiterpene Lactones from Arnica Tincture [PDF]
Pharmaceutics, 2022 Arnica tincture is a traditional herbal medicine used to treat blunt injuries, e.g., bruises and squeezes. In addition, a potential new use in the treatment of cutaneous leishmaniasis is currently under investigation.
Franziska M. Jürgens +3 more
doaj +2 more sources
In vitro dermal absorption of carfentanil.
Toxicology in Vitro, 2020 There is growing concern regarding potential occupational exposures to the ultra-potent synthetic opioid carfentanil. However, little data are available on the toxicity of carfentanil in humans, particularly for dermal exposures. To begin to address this,
E. Lent, K. Maistros, J. Oyler
semanticscholar +4 more sources
Environment InternationalTo overcome ethical and technical challenges impeding the study of human dermal uptake of chemical additives present in microplastics (MPs), we employed 3D human skin equivalent (3D-HSE) models to provide first insights into the dermal bioavailability of
Ovokeroye Akpojevwe Abafe +2 more
doaj +2 more sources
Analytical Method Development and Dermal Absorption of 4-Amino-3-Nitrophenol (4A3NP), a Hair Dye Ingredient under the Oxidative or Non-Oxidative Condition [PDF]
ToxicsThe chemical 4-amino-3-nitrophenol (4A3NP) is classified as an amino nitrophenol and is primarily utilized as an ingredient in hair dye colorants. In Korea and Europe, it is exclusively used in non-oxidative or oxidative hair dye formulations, with ...
Hyang Yeon Kim +4 more
doaj +2 more sources
Assessment of new scientific studies on human in vitro dermal absorption [PDF]
EFSA Journal, 2015 This EFSA scientific report describes the results from the evaluation of new human in vitro studies on dermal absorption made available by European Crop Protection Association (ECPA) and the German public organisation Bundesinstitut für Risikobewertung ...
EFSA Working Group on Dermal Absorption
doaj +2 more sources
Variability Between Datasets and Statistical Approaches—Rethinking Estimation of Default Dermal Absorption Values for Risk Assessment [PDF]
ToxicsIn risk assessment, deriving dermal absorption values is essential for evaluating plant protection products. Applicants submit study data, which authorities assess during the authorisation process.
Veronika Städele +2 more
doaj +2 more sources