Results 11 to 20 of about 75,603 (294)

Retrospective analysis of dermal absorption triple pack data. [PDF]

ALTEX, 2021
Dermal toxicity is driven by the ability of a substance to penetrate the skin. The “triple pack” approach, which combines in vivo rat, in vitro rat, and in vitro human data, is used to calculate an estimated human dermal absorption factor (DAF).
Allen DG, Rooney J, Kleinstreuer N, Lowit A, Perron M.   +4 more
europepmc   +4 more sources

Variability Between Datasets and Statistical Approaches—Rethinking Estimation of Default Dermal Absorption Values for Risk Assessment [PDF]

Toxics
In risk assessment, deriving dermal absorption values is essential for evaluating plant protection products. Applicants submit study data, which authorities assess during the authorisation process.
Veronika Städele, Sabine Martin, Korinna Wend   +2 more
doaj   +2 more sources

Analysis of finite dose dermal absorption data: Implications for dermal exposure assessment [PDF]

Journal of Exposure Science & Environmental Epidemiology, 2013
A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach
Frasch HF, Dotson GS, Bunge AL, Chen C-P, Cherrie JW, Kasting GB, Kissel JC, Sahmel J, Semple S, Wilkinson S   +9 more
openaire   +5 more sources

Identification, Quantification, and Characterization of Microplastics in Skincare and Treatment Creams: A Potential Health Concern Related to the Exposure Pathway [PDF]

Journal of Xenobiotics
This research aimed to quantify and investigate the morphology of microplastics in skincare and treatment creams related to their chemical composition and the potential risks to human health associated with exposure to microplastics by dermal contact.
Raluca Maria Stirbescu, Cristiana Radulescu, Raluca Maria Bucur (Popa), Andreea Laura Banica, Ioan Alin Bucurica, Ioana Daniela Dulama   +5 more
doaj   +2 more sources

A Novel Workflow for Non-Animal PBK Modelling of UV Filters: Oxybenzone as a Case Study [PDF]

Pharmaceuticals
Background/Objectives: Physiologically based kinetics (PBK) modelling provides (internal) exposure concentrations. We used a PBK model parameterized exclusively with in silico and in vitro data in a bottom-up approach to predict the pharmacokinetics of ...
Nazanin Golbamaki, Anne Moustié, Nicola J. Hewitt, Guillaume Lereaux, Matthew Burbank, El Mehdi Ben Yahya, Sébastien Grégoire, Laurène Roussel-Berlier   +7 more
doaj   +2 more sources

Early-Life Exposure to Formaldehyde through Clothing

Toxics, 2022
Clothes contain a wide range of chemicals, some of them potentially hazardous. Recently, there has been a growing interest in eco-friendly clothing, including the use of organic cotton.
Marta Herrero, Neus González, Joaquim Rovira, Montse Marquès, José L. Domingo, Martí Nadal   +5 more
doaj   +1 more source

A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatological drug products

Frontiers in Pharmacology, 2022
Physiologically based pharmacokinetic (PBPK) models are widely accepted tools utilised to describe and predict drug pharmacokinetics (PK). This includes the use of dermal PBPK models at the regulatory level including virtual bioequivalence (VBE) studies.
J. F. Clarke, J. F. Clarke, K. Thakur, S. Polak, S. Polak   +4 more
doaj   +1 more source

Ethanol is indispensable for virucidal hand antisepsis and without toxic risks in daily use

GMS Hygiene and Infection Control, 2023
The approval of ethanol by the Biocidal Products Regulation has been under evaluation since 2007 due to controversial opinions on the risk assessment.
Kramer, Axel, Benkhai, Hicham, Jäkel, Christian, Zwicker, Paula   +3 more
doaj   +1 more source

Pesticide Flow Analysis to Assess Human Exposure in Greenhouse Flower Production in Colombia [PDF]

, 2013
Human exposure assessment tools represent a means for understanding human exposure to pesticides in agricultural activities and managing possible health risks.
Baccini, Baldi, Baldi, Bell, Binder, Brunner, Camilo Lesmes-Fabian, Cherrie, Claudia Binder, Elbaz, Garrod, Garry, Garry, Glass, Hanke, Hardell, Infante-Rivard, Jurewicz, Lesmes-Fabian, Monsó, Richter, Rosano, Salameh, Teubl, van der Voet, Varona, Vitali, Weidner   +27 more
core   +2 more sources

The use of heat and chemical penetration enhancers to increase the follicular delivery of erythromycin to the skin [PDF]

, 2019
Copyright © 2019. Published by Elsevier B.V.The effect of heat on the follicular absorption of drugs into the skin has not previously been investigated.
Akomeah, Alberti, Baden, Butcher, Cada, Coldman, Edwards, F. Caserta, FDA, Feldmann, Goh, Higuchi, ICH, Q2(R1), Kim, Kligman, Liu, M.B. Brown, McAuley, McAuley, Minson, Motwani, Motwani, OECD, Oliveira, Otberg, Park, Piazza, Pierard, Rancan, Saar, Santos, Sato, Shergill, Szabo, Teichmann, Toll, Twist, W.J. McAuley, Wood, Wood, Wood, Yarnitsky, Zhang   +42 more
core   +2 more sources