Results 21 to 30 of about 1,062,941 (282)

A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatological drug products

Frontiers in Pharmacology, 2022
Physiologically based pharmacokinetic (PBPK) models are widely accepted tools utilised to describe and predict drug pharmacokinetics (PK). This includes the use of dermal PBPK models at the regulatory level including virtual bioequivalence (VBE) studies.
J. F. Clarke, J. F. Clarke, K. Thakur, S. Polak, S. Polak   +4 more
doaj   +1 more source

Analysis of finite dose dermal absorption data:Implications for dermal exposure assessment [PDF]

, 2014
A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied ...
Dotson, G. Scott, Sahmel, Jennifer, Wilkinson, Simon, Kasting, Gerald B., John C Kissel, Kasting, Gerald B, Sean Semple, H Frederick Frasch, Simon Wilkinson, Bunge, Annette L., Gerald B Kasting, Jennifer Sahmel, Annette L Bunge, Cherrie, John W.; id_orcid, Cherrie, John W, Kissel, John C., Frasch, H. Frederick, Kissel, John C, Frasch, H Frederick, G Scott Dotson, John W Cherrie, Chen-Peng Chen, Bunge, Annette L, Dotson, G Scott, Chen, Chen-Peng, Semple, Sean, Chen, Chen Peng   +26 more
core   +1 more source

Ethanol is indispensable for virucidal hand antisepsis and without toxic risks in daily use

GMS Hygiene and Infection Control, 2023
The approval of ethanol by the Biocidal Products Regulation has been under evaluation since 2007 due to controversial opinions on the risk assessment.
Kramer, Axel, Benkhai, Hicham, Jäkel, Christian, Zwicker, Paula   +3 more
doaj   +1 more source

In vitro dermal absorption of carfentanil

Toxicology in Vitro, 2020
There is growing concern regarding potential occupational exposures to the ultra-potent synthetic opioid carfentanil. However, little data are available on the toxicity of carfentanil in humans, particularly for dermal exposures. To begin to address this, permeation of carfentanil formulated in three vehicles, water, ethanol, and hand sanitizer was ...
Emily May, Lent, Kathleen J, Maistros, Jonathan M, Oyler   +2 more
openaire   +3 more sources

The mismeasure of dermal absorption [PDF]

Journal of Exposure Science & Environmental Epidemiology, 2010
The results of dermal absorption experiments are routinely and often exclusively reported in terms of fractional absorption. However, fractional absorption is not generally independent of skin loading conditions. As a consequence, experimental outcomes are commonly misinterpreted.
openaire   +2 more sources

Pesticide Flow Analysis to Assess Human Exposure in Greenhouse Flower Production in Colombia [PDF]

, 2013
Human exposure assessment tools represent a means for understanding human exposure to pesticides in agricultural activities and managing possible health risks.
Camilo Lesmes-fabian, Binder, Claudia R., Claudia Binder, Lesmes-Fabian, Camilo, Claudia R. Binder   +4 more
core   +2 more sources

Dermal absorption of testosterone in human and pig skin in vitro [PDF]

, 2018
The OECD test guideline 428 for the assessment of dermal absorption in vitro has been in force for more than a decade. Various sectors of industry utilise the method for the registration of chemical products.

core   +1 more source

Variational finite element method to study the absorption rate of drug at various compartments through transdermal drug delivery system

Alexandria Journal of Medicine, 2015
Background: The delivery of drugs through dermal layers known as transdermal drug delivery is one of the important contributions in medical practice. It represents an alternative to oral drug delivery and is poised to provide a substitute to hypodermic ...
M.A. Khanday, Aasma Rafiq
doaj   +1 more source

Parameters for exposure assessment via oral ingestion and dermal absorption pathway.

, 2023
Parameters for exposure assessment via oral ingestion and dermal absorption pathway.
Ekene Biose (17636897), Ifeanyi Maxwell Ezenwa (17636888), Osariyekemwen Uyi (14229347), Michael Omoigberale (17636891), Rachel Abulu (17636894), Benjamin Okpara (17636900)   +5 more
core   +1 more source

Evaluation of Pharmacokinetic and Toxicological Parameters of Arnica Tincture after Dermal Application In Vivo

Pharmaceutics, 2022
Cutaneous leishmaniasis (CL) is classified as a neglected tropical disease by the World Health Organization. As the standard drugs for the treatment of this disease suffer from severe unwanted effects, new effective and safe therapeutic options are ...
Franziska M. Jürgens, Sara M. Robledo, Thomas J. Schmidt   +2 more
doaj   +1 more source