Assessment of new scientific studies on human in vitro dermal absorption [PDF]
EFSA Journal, 2015 This EFSA scientific report describes the results from the evaluation of new human in vitro studies on dermal absorption made available by European Crop Protection Association (ECPA) and the German public organisation Bundesinstitut für Risikobewertung ...
EFSA Working Group on Dermal Absorption
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Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel [PDF]
Pharmaceutics, 2016 Effective topical therapy of cutaneous fungal diseases requires the delivery of the active agent to the target site in adequate concentrations to produce a pharmacological effect and inhibit the growth of the pathogen.
Mahima Manian +3 more
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Variability Between Datasets and Statistical Approaches—Rethinking Estimation of Default Dermal Absorption Values for Risk Assessment [PDF]
ToxicsIn risk assessment, deriving dermal absorption values is essential for evaluating plant protection products. Applicants submit study data, which authorities assess during the authorisation process.
Veronika Städele +2 more
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Identification, Quantification, and Characterization of Microplastics in Skincare and Treatment Creams: A Potential Health Concern Related to the Exposure Pathway [PDF]
Journal of XenobioticsThis research aimed to quantify and investigate the morphology of microplastics in skincare and treatment creams related to their chemical composition and the potential risks to human health associated with exposure to microplastics by dermal contact.
Raluca Maria Stirbescu +5 more
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A new conceptional model for deriving average dermal absorption estimates from studies with multiple tested concentrations for non-dietary risk assessment of pesticides [PDF]
Archives of Toxicology, 2022 Felix M Kluxen +2 more
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Early-Life Exposure to Formaldehyde through Clothing
Toxics, 2022 Clothes contain a wide range of chemicals, some of them potentially hazardous. Recently, there has been a growing interest in eco-friendly clothing, including the use of organic cotton.
Marta Herrero +5 more
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Frontiers in Pharmacology, 2022 Physiologically based pharmacokinetic (PBPK) models are widely accepted tools utilised to describe and predict drug pharmacokinetics (PK). This includes the use of dermal PBPK models at the regulatory level including virtual bioequivalence (VBE) studies.
J. F. Clarke +4 more
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In vitro dermal absorption of carfentanil
Toxicology in Vitro, 2020 There is growing concern regarding potential occupational exposures to the ultra-potent synthetic opioid carfentanil. However, little data are available on the toxicity of carfentanil in humans, particularly for dermal exposures. To begin to address this, permeation of carfentanil formulated in three vehicles, water, ethanol, and hand sanitizer was ...
Emily May, Lent +2 more
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Ethanol is indispensable for virucidal hand antisepsis and without toxic risks in daily use
GMS Hygiene and Infection Control, 2023 The approval of ethanol by the Biocidal Products Regulation has been under evaluation since 2007 due to controversial opinions on the risk assessment.
Kramer, Axel +3 more
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The mismeasure of dermal absorption [PDF]
Journal of Exposure Science & Environmental Epidemiology, 2010 The results of dermal absorption experiments are routinely and often exclusively reported in terms of fractional absorption. However, fractional absorption is not generally independent of skin loading conditions. As a consequence, experimental outcomes are commonly misinterpreted.
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