Results 31 to 40 of about 35,060 (247)
Alexandria Journal of Medicine, 2015 Background: The delivery of drugs through dermal layers known as transdermal drug delivery is one of the important contributions in medical practice. It represents an alternative to oral drug delivery and is poised to provide a substitute to hypodermic ...
M.A. Khanday, Aasma Rafiq
doaj +1 more source
Pharmaceutics, 2022 Cutaneous leishmaniasis (CL) is classified as a neglected tropical disease by the World Health Organization. As the standard drugs for the treatment of this disease suffer from severe unwanted effects, new effective and safe therapeutic options are ...
Franziska M. Jürgens +2 more
doaj +1 more source
Cosmetics, 2021 Cosmetic products need to have a proven efficacy combined with a comprehensive toxicological assessment. Before the current Cosmetic regulation N°1223/2009, the 7th Amendment to the European Cosmetics Directive has banned animal testing for cosmetic ...
Manon Barthe +10 more
doaj +1 more source
In silico evaluation of the dermal antiaging activity of Molineria latifolia (Dryand. ex W.T. Aiton) Herb. Ex Kurz compounds [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Dermal aging is one of the events caused by a decrease in the structure of skin tissues due to various factors. Molineria latifolia is one of the plants empirically used in medicine and can be developed to treat dermal aging problems.
Syamsu Nur +4 more
doaj +1 more source
Scientific Opinion on the Science behind the Revision of the Guidance Document on Dermal Absorption
EFSA Journal, 2011 This opinion provides the relevant data, evaluations and references that support the criteria proposed in the new draft guidance needed to facilitate assessment of dermal absorption of plant protection products (PPPs) under Directive 91/414/EEC[1] and ...
EFSA Panel on Plant Protection Products and their Residues (PPR)
doaj +1 more source
ToxicsFirefighter occupational exposures were categorized as a class 1 (known) carcinogen by the International Agency for Research on Cancer in 2022. As a result, firefighters have become heavily focused on identifying effective and easy to implement ...
Chandler Probert +2 more
doaj +1 more source
Assessment of occupational and dietary exposure to pesticide residues
EFSA Journal, 2018 Plant protection products (PPPs) are pesticides containing at least one active substance that drives specific actions against pests (diseases). PPPs are regulated in the EU and cannot be placed on the market or used without prior authorisation.
National Institute for Public Health and the Environment (RIVM) The Netherlands +8 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Fatal Dermal Absorption of Organophosphate Insecticide
ProceedingsOrganophosphate compounds are one of the leading causes of death due to poisoning worldwide due to their easy accessibility as insectides and pesticides.
Shankar M Bakkannavar, Vinod C Nayak
doaj +1 more source