Results 31 to 40 of about 1,910,776 (311)

Early-Life Exposure to Formaldehyde through Clothing

Toxics, 2022
Clothes contain a wide range of chemicals, some of them potentially hazardous. Recently, there has been a growing interest in eco-friendly clothing, including the use of organic cotton.
Marta Herrero, Neus González, Joaquim Rovira, Montse Marquès, José L. Domingo, Martí Nadal   +5 more
doaj   +1 more source

Phthalates in skin wipes: Distribution, sources, and exposure via dermal absorption.

Environmental Research, 2021
Phthalates, which are widely used in industrial products, can be dermally absorbed into the human body and harm human health. In this study, we measured the levels of phthalates in skin wipes collected from 30 undergraduate volunteers.
An-ju Zhao, Lixin Wang, Xueying Pang, F. Liu   +3 more
semanticscholar   +1 more source

A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatological drug products

Frontiers in Pharmacology, 2022
Physiologically based pharmacokinetic (PBPK) models are widely accepted tools utilised to describe and predict drug pharmacokinetics (PK). This includes the use of dermal PBPK models at the regulatory level including virtual bioequivalence (VBE) studies.
J. F. Clarke, J. F. Clarke, K. Thakur, S. Polak, S. Polak   +4 more
doaj   +1 more source

Analysis of finite dose dermal absorption data:Implications for dermal exposure assessment [PDF]

, 2014
A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied ...
Dotson, G. Scott, Sahmel, Jennifer, Wilkinson, Simon, Kasting, Gerald B., John C Kissel, Kasting, Gerald B, Sean Semple, H Frederick Frasch, Simon Wilkinson, Bunge, Annette L., Gerald B Kasting, Jennifer Sahmel, Annette L Bunge, Cherrie, John W.; id_orcid, Cherrie, John W, Kissel, John C., Frasch, H. Frederick, Kissel, John C, Frasch, H Frederick, G Scott Dotson, John W Cherrie, Chen-Peng Chen, Bunge, Annette L, Dotson, G Scott, Chen, Chen-Peng, Semple, Sean, Chen, Chen Peng   +26 more
core   +1 more source

Pesticide Flow Analysis to Assess Human Exposure in Greenhouse Flower Production in Colombia [PDF]

, 2013
Human exposure assessment tools represent a means for understanding human exposure to pesticides in agricultural activities and managing possible health risks.
Camilo Lesmes-fabian, Binder, Claudia R., Claudia Binder, Lesmes-Fabian, Camilo, Claudia R. Binder   +4 more
core   +1 more source

The mismeasure of dermal absorption [PDF]

Journal of Exposure Science & Environmental Epidemiology, 2010
The results of dermal absorption experiments are routinely and often exclusively reported in terms of fractional absorption. However, fractional absorption is not generally independent of skin loading conditions. As a consequence, experimental outcomes are commonly misinterpreted.
openaire   +2 more sources

The Phenion (R) Full-Thickness Skin Model for Percutaneous Absorption Testing [PDF]

, 2010
In recent years many efforts have been made to replace dermal toxicity testing of chemicals in the animal by in vitro assays. As a member of a German research consortium, we have previously contributed to the validation of an in vitro test protocol for ...
Korting, Hans Christian, Ackermann, K., Schäfer-Korting, Monika, Borgia, S. Lombardi, Mewes, K. R.   +4 more
core   +1 more source

Dermal Absorption of Inorganic Arsenic from Water [PDF]

, 2003
This white paper explores questions of the potential for exposure to inorganic arsenic in water through dermal contact when providing guidance about treatment options to private well owners.
Post, Gloria
core   +3 more sources

Variational finite element method to study the absorption rate of drug at various compartments through transdermal drug delivery system

Alexandria Journal of Medicine, 2015
Background: The delivery of drugs through dermal layers known as transdermal drug delivery is one of the important contributions in medical practice. It represents an alternative to oral drug delivery and is poised to provide a substitute to hypodermic ...
M.A. Khanday, Aasma Rafiq
doaj   +1 more source

Evaluation of Pharmacokinetic and Toxicological Parameters of Arnica Tincture after Dermal Application In Vivo

Pharmaceutics, 2022
Cutaneous leishmaniasis (CL) is classified as a neglected tropical disease by the World Health Organization. As the standard drugs for the treatment of this disease suffer from severe unwanted effects, new effective and safe therapeutic options are ...
Franziska M. Jürgens, Sara M. Robledo, Thomas J. Schmidt   +2 more
doaj   +1 more source