Results 121 to 130 of about 6,921,908 (377)

Personalized Medicine in Malignant Melanoma: Towards Patient Tailored Treatment

Frontiers in Oncology, 2018
Despite enormous international efforts, skin melanoma is still a major clinical challenge. Melanoma takes a top place among the most common cancer types and it has one of the most rapidly increasing incidences in many countries around the world.
Hildur Helgadottir, Hildur Helgadottir, Iara Rocha Trocoli Drakensjö, Iara Rocha Trocoli Drakensjö, Ada Girnita, Ada Girnita   +5 more
doaj   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Chemoprevention of nonmelanoma skin cancer: experience with a polyphenol from green tea. [PDF]

, 2003
Nonmelanoma skin cancer is extremely common and is increasing in incidence. It would be very useful to have forms of therapy that would prevent precancerous changes from going on to form cancer, or to reverse the precancerous changes.
Barr, Ronald J, Carpenter, Philip M, Hite, Pamela, Li, Kou-Tung, Linden, Kenneth G, McLaren, Christine E, Meyskens, Frank L, Sun, Joannie D, Viner, Jaye L   +8 more
core   +1 more source

Nonmelanoma skin cancer

Journal of Cutaneous and Aesthetic Surgery, 2012
Nonmelanoma skin cancer (NMSC) represents the most common form of cancer in Caucasians, with continuing increase in incidence worldwide. Basal cell carcinoma (BCC) accounts for 75% of cases of NMSC, and squamous cell carcinoma (SCC) accounts for the remaining majority of NMSC cases.
Vishal Madan, Venura Samarasinghe
openaire   +3 more sources

Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Nature Communications, 2020
Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets ...
Mingzhu Yin, Ying Guo, Rui Hu, Wesley L. Cai, Yao Li, Shiyao Pei, Hongyin Sun, Cong Peng, Jiali Li, Rui Ye, Qiaohong Yang, Nenghui Wang, Yongguang Tao, Xiang Chen, Qin Yan   +14 more
doaj   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression

Frontiers in Immunology, 2018
The immune system has many sophisticated mechanisms to balance an extensive immune response. Distinct immunosuppressive cells could protect from excessive tissue damage and autoimmune disorders.
Viktor Fleming, Viktor Fleming, Xiaoying Hu, Xiaoying Hu, Rebekka Weber, Rebekka Weber, Vasyl Nagibin, Vasyl Nagibin, Christopher Groth, Christopher Groth, Peter Altevogt, Peter Altevogt, Jochen Utikal, Jochen Utikal, Viktor Umansky, Viktor Umansky   +15 more
doaj   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Untargeted metabolomics yields insight into extramammary Paget’s disease mechanisms

Frontiers in Oncology
BackgroundExtramammary Paget’s disease (EMPD) is a rare cutaneous malignancy, commonly affecting the external genitalia and perianal area of the elderly with unclear pathogenesis.
Long Jiang, Long Jiang, Xiaoxiang Xu, Xiaoxiang Xu, Guorong Yan, Guorong Yan, Guorong Yan, Yuhao Wu, Yuhao Wu, Yuhao Wu, Ningyuan Xi, Ningyuan Xi, Yongxian Lai, Yongxian Lai, Guolong Zhang, Guolong Zhang, Guolong Zhang, Yeqiang Liu, Yeqiang Liu   +18 more
doaj   +1 more source