Results 121 to 130 of about 4,372,786 (304)

Skin cancer: cancer trends report 2025

Key Points Malignancies of the skin are the most commonly diagnosed cancers in Ireland, with approximately 11,556 cases diagnosed annually in the period between 2018-2022, accounting for 34% of all invasive cancers.
National Cancer Registry Ireland (NCRI)
core  

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among U.S. Veterans

Arthritis Care &Research, Accepted Article.
Biomedical research involving United States Veterans continues to advance healthcare beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where Veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

Targeting CLEC4E in immunosuppressive tumour‐associated macrophages via BET inhibition

Clinical and Translational Medicine
Background Immunosuppressive tumour‐associated macrophages (TAMs) represent a promising target for cancer immunotherapy; however, existing TAM‐directed therapies have shown limited clinical efficacy. C‐type lectin domain family 4 member E (CLEC4E), a pro‐
Mengting Liao, Kexin Long, Liang Dong, Zhuo Li, Wenhua Wang, Rui Hu, Yangyi Zhang, Juan Su, Wu Zhu, Xiang Chen, Mingzhu Yin   +10 more
doaj   +1 more source

Correction: Sumarni et al. Targeting Cutaneous T-Cell Lymphoma Cells by Ingenol Mebutate (PEP005) Correlates with PKCδ Activation, ROS Induction as Well as Downregulation of XIAP and c-FLIP. Cells 2021, 10, 987

Cells
In the original publication [...]
Uly Sumarni, Ulrich Reidel, Jürgen Eberle   +2 more
doaj   +1 more source

Associations of Frailty With the Risk of Incident Cancer and Cancer‐Related Mortality in Veterans With Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective This study investigated the association between frailty and cancer incidence and mortality in patients with rheumatoid arthritis (RA). It aimed to identify how frailty influences cancer risk and cancer‐specific outcomes. Methods This retrospective cohort study analyzed data from the Veterans’ Affairs Rheumatoid Arthritis Registry (2002–2023).
Bhavik Bansal, Aaron Baraff, Katherine Wysham, James S. Andrews, Bryant R. England, Ted R. Mikuls, Joshua Baker, Kaleb Michaud, Alexa Meara, Una Makris, Carolyn Presley, Ariela Orkaby, Namrata Singh   +12 more
wiley   +1 more source

Cancer Trends: Cancer of the pancreas

, 2012
Cancer of the pancreas accounts for approximately 2.5% of all invasive cancers and is the 9th most commonly diagnosed cancer in Ireland.1 Almost 400 cases of pancreatic cancer were diagnosed annually between 1994 and 2010 (Table 1).
National Cancer Registry Ireland (NCRI)
core  

Incidence, Risk Factors and Management of Adverse Events in Contemporary Real‐World Care of Children with Juvenile Idiopathic Arthritis

Arthritis Care &Research, Accepted Article.
Objective We describe the frequency, risk factors, severity, and management of actionable and serious adverse events (AAE and SAE) in children with newly diagnosed Juvenile Idiopathic Arthritis (JIA) in Canada. Methods We enrolled patients within 3 months of JIA diagnosis in the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry,
Bashayer Alnuaimi, Roberta A. Berard, Jean‐Philippe Proulx‐Gauthier, Heinrike Schmeling, Michelle Batthish, Gilles Boire, Adam M. Huber, Dax G. Rumsey, Jaime Guzman, Gaëlle Chédeville, The CAPRI registry Investigators   +10 more
wiley   +1 more source

LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation

Cell Discovery
The role of CD8+ tissue-resident memory T (CD8+ TRM) in inflammation is well established. However, the mechanisms by which CD8+ TRM cells are activated in tissues have remained elusive.
Rundong Jiang, Zhiqin Fang, Yutong Wang, Bo Huang, Junkun Liu, Lam C. Tsoi, Rachael Bogle, Zongbo Zhang, Yehong Kuang, Xin Li, Liang Dong, Liping Jin, Johann E. Gudjonsson, Mingzhu Yin, Xiang Chen   +14 more
doaj   +1 more source

Real‐world effectiveness and safety of secukinumab in giant cell arteritis: an Italian multicentre cohort study

Arthritis Care &Research, Accepted Article.
Objective The objective of this study was to evaluate the real‐world effectiveness and safety of secukinumab in giant cell arteritis (GCA) patients. Methods This multicentre retrospective study included patients with GCA who received secukinumab at 14 Italian centres with at least 6 months of follow‐up.
Luca Iorio, Federica Davanzo, Caterina Ricordi, Milena Bond, Ruggiero Mascolo, Jacopo Mora, Alessandro Tomelleri, Angelo Fassio, Francesca Cuzzocrea, Sara Monti, Edoardo Conticini, Fabiola Atzeni, Paolo Delvino, Carlotta Nannini, Augusta Ortolan, Francesco Pollastri, Ester Vivaldelli, Chiara Marvisi, Paola Toniati, Antonio Brucato, Alessandra Milanesi, Francesca Regola, Enrico Tombetti, Lorenzo Dagna, Roberta Ramonda, Christian Dejaco, Luca Quartuccio, Carlo Salvarani, Roberto Padoan, The Italian Society of Rheumatology Vasculitis Study Group   +29 more
wiley   +1 more source

Integrated longitudinal analysis of ctDNA, radiologic response, and tumor volume reveals spatial and temporal heterogeneity in advanced melanoma

Journal of Translational Medicine
Background In advanced melanoma, longitudinal disease monitoring remains limited by infrequent biomarker assessment and predominantly categorical imaging readouts.
Isabel Heidrich, Anna Streckenbach, Charlotte Rautmann, Hanna Freiberg, Julian Kött, Glenn Geidel, Alessandra Rünger, Tim Zell, Carmen Roeper, Inga Hansen-Abeck, Finn Abeck, Stefan W. Schneider, Daniel J. Smit, Klaus Pantel, Christoffer Gebhardt   +14 more
doaj   +1 more source