Results 51 to 60 of about 5,050,584 (299)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ways to increase the effectiveness of skin cancer prevention through early diagnosis and screening of precancerous conditions in risk groups

Лечащий Врач
Background. Skin cancer is one of the most common cancers in the world, but its prevention and early diagnosis remain insufficiently effective.Objective.
M. V. Schetkina
doaj   +1 more source

Global controversies and advances in skin cancer

, 2013
Advances and controversies of skin cancer prevention in the Asian-Pacific region are to be examined in the world's first Global Controversies and Advances in Skin Cancer Conference to be held in Brisbane, Australia this November.
Dunn, Jeff, Baldwin, Louise
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Prevention of Occupational Skin Cancer Caused by Solar Ultraviolet Radiation Exposure: Recent Achievements and Perspectives

Dermato
In fair-skinned populations worldwide, skin cancer is a serious public health threat. A significant percentage of all reported occupational diseases fall back on skin cancer.
Cara Symanzik, Swen M. John
doaj   +1 more source

National Skin Cancer Prevention Plan 2023-2026

, 2023
The National Cancer Strategy 2017-20261 aims to reduce the cancer burden in Ireland. Cancer prevention is a cornerstone of the National Cancer Strategy as it offers the most cost-effective, long-term approach for cancer control.
National Cancer Control Programme
core  

‘I am not someone who gets skin cancer’: Risk, time and malignant melanoma [PDF]

, 2013
‘Delay’ is a term used in the cancer literature since the 1930s to describe the period between self-detection of a concerning sign of possible disease and presentation to a health professional.
Heyman, Bob, Topping, Annie, Topping, A.; id_orcid, Nkosana-Nyawata, I., Nkosana-Nyawata, Idah, Heyman, B.   +5 more
core   +1 more source

Incongruence between Physician, Patient, and Medical Chart Report of Skin Cancer Prevention Counseling

, 2022
Skin cancer incidence in the United States has risen rapidly in recent decades, underscoring the need for accessible and effective prevention practices.
Weinstock, Martin A., Martin A. Weinstock, Natalie H. Matthews, Matthews, Natalie H., Augustine W. Kang, Patricia Markham Risica, Kang, Augustine W., Risica, Patricia Markham   +7 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source