Results 61 to 70 of about 389,808 (302)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Assessment of postgraduate skin lesion education among Iowa family physicians
SAGE Open Medicine, 2017 Background: Family medicine physicians play a pivotal role in the prevention and early detection of skin cancer. Our objective was to evaluate how family physicians believe their postgraduate training in skin cancer screening and prevention has prepared ...
Nicholas J Goetsch +5 more
doaj +1 more source
Revista Brasileira em Promoção da Saúde, 2012 Objectives: To evaluate the correlation between the diagnoses of skin cancer and known risk factors through analysis of data from the National Skin Cancer Prevention Campaign held by Brazilian Society of Dermatology in the state of Piauí, Brazil, in ...
Rafael Bandeira Lages +4 more
doaj +1 more source
Starfished in the sand : developing the theory of planned behaviour to predict intentions to use sunscreen on the beach : a research project presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University, Albany, Auckland, New Zealand [PDF]
, 2003 This study examined the predictive power of the theory of planned behaviour in explaining sunscreen use intentions among beach-goers in New Zealand (n = 148) and the United Kingdom (n = 280). Generally, the theory of planned behaviour performed well with
Neil, Tessa Anne
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Isn't Skin Cancer Preventable? [PDF]
JNCI Journal of the National Cancer Institute, 1992 EDITORIAL Isn't Skin Cancer Preventable? Frank L. Meyskens, Jr.* What are the implications for cancer chemoprevention in humans as reported in the negative study by Tangrea et al. (7) in this issue of the Journal? Impeccably conducted, this multi- center, randomized clinical trial convincingly demonstrated that a low dose of isotretinoin did not ...
openaire +3 more sources
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source