Results 1 to 10 of about 2,216,863 (314)

Bioengineered Skin Intended for Skin Disease Modeling [PDF]

International Journal of Molecular Sciences, 2019
Clinical use of bioengineered skin in reconstructive surgery has been established for more than 30 years. The limitations and ethical considerations regarding the use of animal models have expanded the application of bioengineered skin in the areas of disease modeling and drug screening.
Stephan Cecil Fox, Lidy E Fratila-Apachitei, Amir A Zadpoor   +2 more
exaly   +6 more sources

Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma

Journal of Nanobiotechnology, 2023
Background Topical anticancer drugs offer a potential therapeutic modality with high compliance for treating cutaneous squamous cell carcinoma (cSCC). However, the existing topical treatments for cSCC are associated with limited penetrating ability to ...
Ying Li, Zongguang Tai, Jinyuan Ma, Fengze Miao, Rujuan Xin, Cuie Shen, Min Shen, Quangang Zhu, Zhongjian Chen   +8 more
doaj   +1 more source

Impact of COVID-19 pandemic on the epidemiology of STDs in China: based on the GM (1,1) model

BMC Infectious Diseases, 2022
Background COVID-19 and Sexually Transmitted Diseases (STDs) are two very important diseases. However, relevant researches about how COVID-19 pandemic has impacted on the epidemiological trend of STDs are limited in China. This study aimed to analyze the
Jingmin Yan, Yanbo Li, Pingyu Zhou
doaj   +1 more source

Platelet Indices Are the Promising Biomarkers in Monitoring Disease Activities in Patients with Syphilis

International Journal of Infectious Diseases, 2022
Objectives: To uncover the role of the platelet indices in patients with syphilis. Methods: A total of 2061 patients with syphilis and 528 healthy controls were enrolled in this retrospective cohort study.
Nanyan Jiang, Meiping Ye, Jingmin Yan, Chunjie Liao, Mengya Shang, Guixuan Wang, Ruirui Peng, Juan Wu, Tengfei Qi, Liyan Ni, Zhifang Guan, Wei Zhao, Pingyu Zhou   +12 more
doaj   +1 more source

Single-cell transcriptomic analysis reveals the critical molecular pattern of UV-induced cutaneous squamous cell carcinoma

Cell Death and Disease, 2021
Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer characterized by high invasiveness, heterogeneity, and mainly occurs in the ultraviolet (UV)-exposed regions of the skin, but its pathogenesis is still unclear ...
Guorong Yan, Liang Li, Sibo Zhu, Yuhao Wu, Yeqiang Liu, Lude Zhu, Zijun Zhao, Fei Wu, Ning Jia, Caihe Liao, Long Jiang, Qingyu Zeng, Peiru Wang, Lei Shi, Zhe Zheng, Shan Fang, Guolong Zhang, Yichen Tang, Xiuli Wang   +18 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Evaluation of the efficacy and safety of ionic liquids containing ketoconazole in patients with tinea pedis: A randomized controlled clinical trial

Bioengineering & Translational Medicine, 2023
Ionic liquids (ILs) loading ketoconazole (KCZ) have shown better efficacy on rats with tinea pedis than the marketed Daktarin® but clinical studies are still lacking.
Xiying Wu, Min Shen, Huan Wang, Xue He, Jingwen Tan, Ruiping Wang, Lianjuan Yang, Hong Yang, Jianping Qi, Zhongjian Chen, Quangang Zhu   +10 more
doaj   +1 more source

Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis

BMC Infectious Diseases, 2020
Background Estimating prevalence of Chlamydia trachomatis (CT) worldwide is necessary in designing control programs and allocating health resources. We performed a meta-analysis to calculate the prevalence of CT in the general population.
Pengcheng Huai, Furong Li, Tongsheng Chu, Dianchang Liu, Jian Liu, Furen Zhang   +5 more
doaj   +1 more source

TLR7-MyD88-DC-CXCL16 axis results neutrophil activation to elicit inflammatory response in pustular psoriasis

Cell Death and Disease, 2023
Pustular psoriasis (PP) is a chronic inflammatory disease associated with multiple complications, often with hyperthermia and hypoproteinemia, and its continued progression can be life-threatening.
Jiajing Lu, Xiaoyuan Zhong, Chunyuan Guo, Li Tang, Ning Yu, Chen Peng, Yangfeng Ding, Xunxia Bao, Jing Zhou, Yuling Shi   +9 more
doaj   +1 more source

Skin Microbiome in Disease States: Atopic Dermatitis and Immunodeficiency [PDF]

, 2010
The Human Microbiome Project seeks to explore the diversity of microbiota that resides in and on the human body, including the skin, in health and disease.
Heidi Kong, Julia Segre
core   +2 more sources