Results 21 to 30 of about 2,216,863 (314)

Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]

, 2020
Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M, Cau, Laura, Dupont, Christopher L, Gallo, Richard L, Horswill, Alexander R, Hovnanian, Alain, Kaul, Drishti, Khalil, Shadi, Sanford, James A, Wang, Yichen, Williams, Michael R, Zaramela, Livia S, Zengler, Karsten   +12 more
core  

RNA modifications: importance in immune cell biology and related diseases

Signal Transduction and Targeted Therapy, 2022
RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology.
Lian Cui, Rui Ma, Jiangluyi Cai, Chunyuan Guo, Zeyu Chen, Lingling Yao, Yuanyuan Wang, Rui Fan, Xin Wang, Yuling Shi   +9 more
doaj   +1 more source

Exceptional and Durable Responses to TDM-1 After Trastuzumab Failure for Breast Cancer Skin Metastases: Potential Implications of an Immunological Sanctuary [PDF]

, 2018
Breast Cancer (BC) skin metastases represent a challenging clinical scenario. Although they usually arise when other distant metastases are already present, they may also represent a form of locoregional recurrence (LRR). Systemic therapy in this setting
Dieci, Maria V, Evangelista, Laura, Giarratano, Tommaso, Giorgi, Carlo A, Guarneri, Valentina, Michieletto, Silvia, Miglietta, Federica, Polico, Ilaria, Tsvetkova, Vassilena   +8 more
core   +1 more source

Association between vitamin d deficiencies in sarcoidosis with disease activity, course of disease and stages of lung involvements [PDF]

, 2017
Background: Despite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency
Abedini, A, Adcock, IM, Kazempour-Dizaji, M, Kiani, A, Mirenayat, MS, Mortaz, E, Taghavi, K   +6 more
core   +1 more source

Gonorrhoea among China’s aging population: a 20-year nationwide analysis of epidemiological trends with 5-year projections

Frontiers in Public Health
BackgroundAdvances in longevity and pharmacological interventions have facilitated sustained sexual activity among older adults, increasing their vulnerability to sexually transmitted infections.
Rui-Rui Peng, Zuo-Xi Chen, Juan Wu, Mei Shi, Xin Zheng, Chun-Jie Liao, Lin Zhu, Xiang-Dong Gong, Fu-Quan Long   +8 more
doaj   +1 more source

T cell co-stimulatory and co-inhibitory pathways in atopic dermatitis

Frontiers in Immunology, 2023
The use of immune checkpoint inhibitors (ICIs) targeting the T cell inhibitory pathways has revolutionized cancer treatment. However, ICIs might induce progressive atopic dermatitis (AD) by affecting T cell reactivation.
Chunjiao Zheng, Yuling Shi, Ying Zou
doaj   +1 more source

Skin Mast Cells Contribute to Sporothrix schenckii Infection [PDF]

, 2020
Background: Sporothrix schenckii (S. schenckii), a dimorphic fungus, causes sporotrichosis. Mast cells (MCs) have been described to be involved in skin fungal infections. The role of MCs in cutaneous sporotrichosis remains largely unknown. Objectives:
Frischbutter, Stefan, Geng, Peng, Jiao, Qingqing, Li, Ruoyu, Luo, Ying, Maurer, Marcus, Scheffel, Jörg, Wang, Yuhan, Zhao, Zuotao   +8 more
core   +1 more source

Single-system Langerhans Cell Histiocytosis with Skin Ulcers as the Initial Presentation

Acta Dermato-Venereologica
is missing (Short communication)
Xue-min Wang, Ye-qiang Liu, Bin Li, Ming Li, Yan Peng, Wen-cheng Jiang   +5 more
doaj   +1 more source

Distinct antibody clones detect PD-1 checkpoint expression and block PD-L1 interactions on live murine melanoma cells

Scientific Reports, 2022
Monoclonal antibodies (abs) targeting the programmed cell death 1 (PD-1) immune checkpoint pathway have revolutionized tumor therapy. Because T-cell-directed PD-1 blockade boosts tumor immunity, anti-PD-1 abs have been developed for examining T-cell-PD-1
Christina Martins, Mariana Silva, Erik Rasbach, Praveen Singh, Yuta Itoh, Jason B. Williams, Edith Statham, Anna Meurer, Daniela V. Martinez, Anne Brandenburg, Markus V. Heppt, Steven R. Barthel, Tobias Schatton   +12 more
doaj   +1 more source

Secukinumab treatment in a pediatric patient with corticosteroid-intolerant pyoderma gangrenosum: a case report

Frontiers in Medicine
Pyoderma gangrenosum (PG) is a rare, rapidly progressive, non-infectious neutrophilic dermatosis characterized by severely painful ulcers. Its pathogenesis may be attributed to genetic factors, autoimmune dysfunction, and neutrophil disorders ...
Wang Liwei, Qian Yihong, Tan Fei, Yuan Chao   +3 more
doaj   +1 more source