Results 71 to 80 of about 2,216,863 (314)

TDO2 + cancer-associated fibroblasts mediate cutaneous squamous cell carcinoma immune escape via impeding infiltration of CD8 + T cells

Cancer Immunology, Immunotherapy
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, originating from the malignant proliferation of squamous epithelial cells. However, its pathogenesis remains unclear.
Fangqi Lu, Guorong Yan, Zijun Zhao, Zhe Zheng, Yuhao Wu, Long Wen, Yeqaing Liu, Qingyu Zeng, Guolong Zhang   +8 more
doaj   +1 more source

Acquired epidermodysplasia verruciformis due to multiple and unusual HPV infection among vertically-infected, HIV-positive adolescents in Zimbabwe. [PDF]

, 2012
BACKGROUND: We have previously described the presentation of epidermodysplasia verruciformis (EV)-like eruptions in almost a quarter of hospitalized adolescents with vertically-acquired human immunodeficiency virus (HIV) infection in Harare, Zimbabwe, a ...
Bunker, CB, Corbett, EL, de Koning, M, Ferrand, RA, Katsidzira, L, Lowe, SM, Meys, R, Miller, RF, Munyati, S, Nathoo, K, Ndhlovu, CE, Quint, W, Salisbury, JR, Sterling, JC   +13 more
core   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

IL-27 signaling mediates skin inflammation in experimental psoriasis and atopic dermatitis

Cell & Bioscience
Background Psoriasis and atopic dermatitis (AD) are two prevalent inflammatory skin disorders, each characterized by distinct adaptive immune responses.
Zeyu Chen, Lian Cui, Zhiyi Lan, Suyang Lin, Nan Yang, Siqi Li, Zihan Zhao, Jiangluyi Cai, Yuanyuan Wang, Tong Liu, Yingyuan Yu, Jiajing Lu, Xilin Zhang, Chunyuan Guo, Jun Gu, Qian Yu, Yuling Shi   +16 more
doaj   +1 more source

Could Inflammaging and Its Sequelae Be Prevented or Mitigated? [PDF]

, 2019
Aged humans display a chronic and low-grade inflammation, termed "inflammaging", which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular ...
Elias, Peter M, Man, Mao-Qiang
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Factors associated with cerebrospinal fluid abnormalities suggestive of neurosyphilis in HIV-negative patients with secondary syphilis: a retrospective study

Frontiers in Medicine
ObjectiveTo identify clinical and laboratory factors associated with cerebrospinal fluid (CSF) abnormalities suggestive of neurosyphilis (NS) among HIV-negative patients with secondary syphilis.MethodsWe conducted a retrospective analysis of 805 HIV ...
Lin Zhu, Xin Gu, Liyan Ni, Wei Zhao, Zhifang Guan, Haikong Lu, Pingyu Zhou   +6 more
doaj   +1 more source

Mycobacterium ulcerans infection: control, diagnosis, and treatment. [PDF]

, 2006
The skin disease Buruli ulcer, caused by Mycobacterium ulcerans, is the third most common mycobacterial disease after tuberculosis and leprosy and mainly affects remote rural African communities. Although the disease is known to be linked to contaminated
Adjei, Amofah, Amofah, Andries, Aujoulat, Bentoucha, Darie, Debacker, Debacker, Debacker, Dega, Dega, Dhople, Dhople, Dhople, Drummond, Eddyani, Eric Comte, Espey, Etuaful, Evans, Evans, Fabienne Nackers, Fehr, Françoise Portaels, Guédénon, Hospers, Huygen, Johnson, Johnson, Johnson, Kanga, Kanga, Kanga, Klutse, Marsollier, Marsollier, Marsollier, Marsollier, Marsollier, Marston, Meyers, Mve-Obiang, Nakanaga, Noeske, Okenu, Phillips, Phillips, Portaels, Pszolla, Raghunathan, Revill, Rhodes, Scott, Siegmund, Smith, Stienstra, Stienstra, Stragier, Tanghe, Thangaraj, van der Werf, van der Werf, Veitch, Vinciane Sizaire   +64 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The Value of High-Frequency Ultrasound in the Evaluation of Cutaneous Rosai-Dorfman Disease: A Case Series and Literature Review

Diagnostics
Background and Clinical Significance: Cutaneous Rosai-Dorfman disease (CRDD) is a rare, benign histiocytic proliferative disorder, accounting for approximately 3% of all Rosai-Dorfman disease (RDD) cases.
Leyan Yang, Minjie Shu, Shuqing Sheng, Haoxuan Liu, Jinyi Deng, Yujing Zhao, Qiao Wang, Lehang Guo   +7 more
doaj   +1 more source