Results 191 to 200 of about 326,938 (260)

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

First reported case of human Camelpox in Qatar: A case report. [PDF]

IDCases
Hamad H, Koleri J, Parengal J, Abdulmajed A, Kacem MABH, Hamed M, Coyle P, Maslamani MA.   +7 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Atopic march protocol involving sequential skin and lung inflammation elicited by epicutaneous Staphylococcus aureus and allergen exposure. [PDF]

STAR Protoc
Kline SN, Feller LE, Wills D, Damarla R, Archer NK.   +4 more
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Post-Varicella Purpura Fulminans With Extensive Skin Necrosis in a Child. [PDF]

EJHaem
Correia Pires M, Costa E Castro A, Marujo F, Valsassina R, Patena Forte J, de Pais de Faria J.   +5 more
europepmc   +1 more source

Integrated action for skin NTDs: Deconstructing transmission, addressing knowledge gaps, and championing one health strategies. [PDF]

Nat Commun
Mosi L, Acharya B, Asiedu K, Bamisaiye A, Benbow ME, De Souza D, Elson L, Fahal A, Hay R, Nyangacha R, Quaye C, Shitu Sa'id A, Smith DJ, Jordan H.   +13 more
europepmc   +1 more source

Extensive skin ulcerations in an HIV-positive patient with AIDS: An atypical giant acquired perforating dermatosis-chronic prurigo spectrum presentation. [PDF]

JAAD Case Rep
Podoļanskis J, Nevidovska K, Mahmajeva O, Ābeltiņa K, Kalnbērza L.   +4 more
europepmc   +1 more source

Blau syndrome with atrophoderma vermiculata-like appearance: a case report. [PDF]

Front Immunol
Zheng J, Sun J.
europepmc   +1 more source

Clinical Characteristics and Management of Non-Tuberculous Mycobacterial Skin and Soft Tissue Infections: A Retrospective Cohort Study. [PDF]

Open Forum Infect Dis
Peeters W, van Lier C, van Ingen J, van Houdt C, van Crevel R, van Hees C, Bax H, van den Reek J, van Laarhoven A.   +8 more
europepmc   +1 more source