Results 51 to 60 of about 545,841 (228)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Preschool Case of Staphylococcal Scalded Skin Syndrome: Challenges in Recognition and Care

Case Reports in Dermatological Medicine
Staphylococcal scalded skin syndrome (SSSS) is a rare, toxin-mediated dermatosis in children that can mimic bullous impetigo or other severe blistering disorders.
Ante Damjanović, Ivana Topić, Daniela Kraljević, Svjetlana Mikulić, Eva Jelavić, Marina Čović, Božo Šušak   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cluster analysis to define distinct clinical phenotypes among septic patients with bloodstream infections [PDF]

, 2019
Prior attempts at identifying outcome determinants associated with bloodstream infection have employed a priori determined classification schemes based on readily identifiable microbiology, infection site, and patient characteristics.
Bernauer, Michael, Kollef, Marin H., Micek, Scott T., Vazquez Guilamet, Maria Cristina   +3 more
core   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Histopathological spectrum of skin diseases in a tertiary skin health and referral centre

Journal of Pathology of Nepal, 2019
Background: Skin diseases are very much prevalent in the developing countries. The pattern of skin diseases varies from country to country and even region to region within a country.
Ram Chandra Adhikari, Mahesh Shah, Anjani Kumar Jha   +2 more
doaj   +1 more source

Prevention of infectious diseases in athletes. [PDF]

, 2007
The sports medicine physician may face challenging issues regarding infectious diseases when dealing with teams or highly competitive athletes who have difficulties taking time off to recover.
d'Hemecourt, Pierre, Luke, Anthony
core  

Clinical and epidemiological evolution of sheep pox in Morocco [PDF]

, 2019
Sheep pox is an infectious viral disease that affects specifically sheep and it is caused by the Capripoxvirus genus. The clinical signs include fever, diarrhea, difficulty breathing, nodules, lung lesions and death.
De Clercq, Kris, Ennaji, Mustapha, Haegeman, Andy, Khayli, Mounir, Lafar, Sara, Lancelot, Renaud, Zro, Khalil   +6 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Risk of Superficial Fungal Infections in WHIM Syndrome

Dermatology and Therapy
Introduction WHIM syndrome is a rare autosomal dominant inborn error of immunity caused by gain-of-function mutations in the chemokine receptor CXCR4. Patients with WHIM syndrome frequently suffer from an increased risk for bacterial and viral infections,
Jennifer Strong, Rutha Adhanom, Caleb S. Kim, Yoshine Saito, Jasmine C. Meltzer, Patrick Hallaert, Sophia Martinez, Abigail Salancy, Heidi H. Kong, Edward W. Cowen, Leslie Castelo-Soccio, Philip M. Murphy, David H. McDermott, Isaac Brownell   +13 more
doaj   +1 more source