Results 131 to 140 of about 13,295,690 (363)

Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

Association between vitamin d deficiencies in sarcoidosis with disease activity, course of disease and stages of lung involvements [PDF]

, 2017
Background: Despite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency
Abedini, A, Adcock, IM, Kazempour-Dizaji, M, Kiani, A, Mirenayat, MS, Mortaz, E, Taghavi, K   +6 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A survey on utilization of data mining approaches for dermatological (skin) diseases prediction [PDF]

, 2011
Due to recent technology advances, large volumes of medical data is obtained. These data contain valuable information. Therefore data mining techniques can be used to extract useful patterns.
Adibi, N, Ahmadzadeh, MR, Barati, E, Mohammadi, A, Saraee, MH   +4 more
core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Unraveling the ECM-Immune Cell Crosstalk in Skin Diseases

Front. Cell Dev. Biol., 2019
The extracellular matrix (ECM) is a complex network of proteins and proteoglycans secreted by keratinocytes, fibroblasts and immune cells. The function of the skin ECM has expanded from being a scaffold that provides structural integrity, to a more ...
Oindrila Bhattacharjee, Uttkarsh Ayyangar, Ambika S. Kurbet, Driti Ashok, Srikala Raghavan   +4 more
semanticscholar   +1 more source

Automatic fluorescence microscopic image analyzer: a novel AI-based tool for early diagnosing superficial fungal infections

BMC Infectious Diseases
Background Superficial fungal infections (SFIs) are highly prevalent globally, affecting approximately 20–25% of the population. Their diverse and often non-specific clinical manifestations necessitate accurate and timely laboratory diagnosis ...
Wenjing He, Chunjiao Zheng, Lianjuan Yang, Jingwen Tan   +3 more
doaj   +1 more source

A case of generalized eosinophilic pustular folliculitis: treatment with JAK inhibitor

Journal of Dermatological Treatment
Aim This case study aims to report the efficacy and safety of a Janus kinase (JAK) inhibitor in the treatment of generalized eosinophilic pustular folliculitis (EPF).Methods We present a case of a 16-year-old Chinese patient who had been suffering from ...
Chunzhi Zheng, Yueqian Yu, Guizhi Zhou, Hong Liu   +3 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Comorbidities in Discoid Lupus: A Systematic Review and Meta-analysis of Prevalence and Association

Dermatology and Therapy
Introduction Discoid lupus erythematosus (DLE) is a chronic inflammatory scarring alopecia that may be accompanied by a broad range of systemic and extracutaneous comorbidities.
Juan Luis Sanz-Cabanillas, Francisco José Gómez-García, Elena Beatriz Sanz-Cabanillas, Jesús Gay-Mimbrera, Beatriz Isla-Tejera, Antonio José Vélez García-Nieto, Juan Ruano   +6 more
doaj   +1 more source