Results 111 to 120 of about 13,295,690 (363)

Somatic Variants of KRT1/KRT10 Identified by Next-generation Sequencing in Patients with Epidermal Nevi

Acta Dermato-Venereologica
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Shuya Sun, Ran Mo, Zhiming Chen, Yong Yang, Ruiyu Xiang   +4 more
doaj   +1 more source

Universal in vivo Textural Model for Human Skin based on Optical Coherence Tomograms

, 2017
Currently, diagnosis of skin diseases is based primarily on visual pattern recognition skills and expertise of the physician observing the lesion. Even though dermatologists are trained to recognize patterns of morphology, it is still a subjective visual
Adabi, Saba, Clayton, Anne, Conforto, Silvia, Daveluy, Steven, Hosseinzadeh, Matin, Mehregan, Darius, Nasiriavanaki, Mohammadreza, Noei, Shahryar   +7 more
core   +2 more sources

MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression [PDF]

, 2016
FUNDING This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR44877]; the National Institutes for Dental and Craniofacial Research [5T90DE21989]; a Grant-in-Aid award ...
Delany, Anne M, Dole, Neha S, Franceschetti, Tiziana, Hrdlicka, Henry C, Smith, Spenser S   +4 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cutaneous Nontuberculous Mycobacteria Infections Following Cosmetic Procedures: A Retrospective Study

Infection and Drug Resistance
Rui Zeng,1,2,* Jingshu Xiong,1– 3,* Wei Gao,4 Jiayi Peng,1,2 Ying Shi,1– 3 Wenyue Zhang,1– 3 Haiqin Jiang,1– 3 Chaojiang Cheng,1,2 Gai Ge,5 Zhenzhen Wang,1,2 Youming Mei,1– 3 Zhiming Chen,6 Hongsheng Wang1– 3,7 1Hospital for Skin Diseases,
Zeng R, Xiong J, Gao W, Peng J, Shi Y, Zhang W, Jiang H, Cheng C, Ge G, Wang Z, Mei Y, Chen Z, Wang H   +12 more
doaj  

Tricyclazole alleviates Fonsecaea pedrosoi-induced immune suppression of neutrophils by inhibiting DHN-melanin biosynthesis

Frontiers in Cellular and Infection Microbiology
IntroductionChromoblastomycosis (CBM) is a chronic cutaneous infection caused by dematiaceous fungi, characterized by therapeutic challenges such as difficulty in pathogen clearance and high recurrence rates. Fonsecaea pedrosoi (F.
Chunjiao Zheng, Wei Li, Yuanyuan Wang, Lulu Li, Linan Ni, Xiaoping Liu, Jingwen Tan, Lianjuan Yang, Qian Yu   +8 more
doaj   +1 more source

Classification of Human Skin Diseases using Data Mining [PDF]

, 2017
Many Information can be extracted from the data that are hidden in images. The extraction process can be done using data mining techniques. In this paper, the researcher will use a system based on the decision tree for mining and processing image data ...
Kadhim, Q. K. (Qusay)
core   +1 more source