Results 101 to 110 of about 13,295,690 (363)

Targeting the Janus Kinase Family in Autoimmune Skin Diseases

Frontiers in Immunology, 2019
Autoimmune skin diseases are characterized by significant local and systemic inflammation that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway.
M. Howell, F. Kuo, Paul A. Smith
semanticscholar   +1 more source

Circular RNA: a novel potential biomarker for skin diseases.

Pharmacological Research, 2020
Circular RNA (circRNA) has been classified as noncoding RNA with a covalent closed continuous loop, the 3'and 5' ends of which are normally joined together to increase its own stability. More recently, circRNA has been shown to encode proteins and may be
Xiaoting Wu, Yanwei Xiao, Jingxin Ma, Aoxue Wang   +3 more
semanticscholar   +1 more source

Assessment of Occupational Diseases among Artisans and Factory Workers in Ifo, Nigeria [PDF]

, 2013
The ever increasing incidences of occupational diseases among workers have continually drawn the attention of researchers towards ameliorating the situation.
Dahunsi, S. O., Idowu, S. A., Oranusi, S. U.   +2 more
core  

Emerging Topical and Systemic JAK Inhibitors in Dermatology [PDF]

, 2019
Accumulating data on cellular and molecular pathways help to develop novel therapeutic strategies in skin inflammation and autoimmunity. Examples are psoriasis and atopic dermatitis, two clinically and immunologically well-defined disorders.
Ghoreschi, Kamran, Meier, Katharina, Solimani, Farzan   +2 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

A Case Report of JAK Inhibitors Therapy for Adult-Onset Still’s Disease with Persistent Pruritic Lesions

Drugs in R&D
Background and Objective Adult-onset Still’s disease (AOSD) is a recognized autoinflammatory disorder of unknown etiology. The standard initial management for AOSD includes conventional corticosteroids and disease-modifying antirheumatic drugs.
Li Tang, Hongjian Shi, Weijun Liu, Pingxiu He, Chun Huang, Xiaobing Wang   +5 more
doaj   +1 more source

Successful treatment of a case of dupilumab-induced psoriasis and alopecia areata with tofacitinib

Pifu-xingbing zhenliaoxue zazhi
We report a case of dupilumab-induced alopecia areata and psoriasis successfully treated with a JAK inhibitor. A 33-year-old woman presented with recurrent erythema and itching for over 10 years.
SUN Feifei, QIU Xiaoye, PAN Futang
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases

Frontiers in Immunology, 2019
Tyrosine kinases relay signals from diverse leukocyte antigen receptors, innate immune receptors, and cytokine receptors, and therefore mediate the recruitment and activation of various leukocyte populations. Non-receptor tyrosine kinases of the Jak, Src,
K. Szilveszter, T. Németh, A. Mócsai
semanticscholar   +1 more source

Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation

Cell Death and Disease
Gasdermin E (GSDME) has recently been identified as a critical executioner to mediate pyroptosis. While epidermal keratinocytes can initiate GSDME-mediated pyroptosis, the role of keratinocyte GSDME in psoriatic dermatitis remains poorly characterized ...
Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen   +10 more
doaj   +1 more source