Results 211 to 220 of about 24,301 (250)

Ectodermal Dysplasia-Skin Fragility Syndrome

Dermatologic Clinics, 2010
Pathogenic mutations have now been described in ten different desmosomal proteins: plakophilin 1 (PKP1) and 2 (PKP2); desmoplakin; plakoglobin; desmoglein 1, 2, and 4; desmocollin 2, and 3 corneodesmosin. Nevertheless, the first report of an inherited desmosomal gene disorder, published in 1997, involved loss-of-function mutations on both alleles of ...
McGrath, John A, Mellerio, Jemima E
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A 2-Year-Old Girl With Skin Fragility

JAMA Dermatology, 2015
A2-year-oldgirlwas referred toour department for skin fragility since early infancy.Shehad2olderbrothers,andthefamilyhadnomedicalhistoryofnote.Physical examination revealedmildxerosiswithsuperficial skinerosionsanderythematousresidualmaculesfrompreviouserosions.
Juan Francisco, Mir-Bonafe, Eulalia, Baselga-Torres, Rogelio, Gonzalez-Sarmiento   +2 more
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Isotretinoin-Induced Skin Fragility in an Aerialist

Cutis
Isotretinoin is widely used for treatment of severe cystic acne; however, its use is accompanied by mucocutaneous adverse effects. The established protocol for conducting cutaneous procedures on patients undergoing current or recent treatment with isotretinoin recommends a cessation period of at least 6 months to mitigate risks for delayed wound ...
Helana, Ghali, Sharon E, Albers
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Wounding Earth's Fragile Skin

Science, 2004
Soil degradation in all its nefarious forms is not a prelude to mass starvation, as analysts once feared. Nevertheless, it is eroding crop yields and contributing to malnourishment in many corners of the globe.
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Focal adhesions in the skin: lessons learned from skin fragility disorders

European Journal of Dermatology, 2017
Focal adhesions are large multiprotein cell-matrix adhesion complexes, which regulate multiple cellular functions, such as adhesion and migration. Their biological significance in skin is underscored by two genetic disorders, the Kindler syndrome and the interstitial lung disease, nephrotic syndrome and epidermolysis bullosa, in which mutations affect ...
Cristina, Has, Yinghong, He
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Suturing of fragile skin

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2009
M D, Pacifico, R P, Teixeira, M, Ritz
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Fragility: Skin in the Game

2022
Li Way Lee, Aaron Keathley
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[Skin fragility in autoimmune blistering diseases of the skin].

Dermatologie (Heidelberg, Germany)
In many disorders, skin and/or mucosal changes are dominated by blisters, wounds, or erosions. While these changes can be observed during infective, traumatic, metabolic, or inflammatory processes, these are normally clinical hallmarks of the disruption of the cytoarchitectural stability of the skin.
Farzan, Solimani, Dario, Didona, Michael, Hertl   +2 more
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[Molecular pathology of skin fragility].

Dermatologie (Heidelberg, Germany)
The skin's barrier function is primarily maintained by the cohesion of its layers and the specialized stratum corneum. Genetic and autoimmune disorders that result in skin fragility have significantly contributed to understanding the role of various molecular components in the skin.
Cristina, Has, Meropi, Karakioulaki
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[The many facets of inherited skin fragility].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2015
The inherited skin fragility encompasses a heterogeneous group of disorders, collectively designated as epidermolysis bullosa, characterized by recurrent mechanically induced blisters, erosions or wounds. The spectrum of clinical manifestations is broad, as well as the molecular background.
C, Has, D, Kiritsi
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