Results 261 to 270 of about 2,027,719 (303)
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Tight junctions in skin inflammation
Pflügers Archiv - European Journal of Physiology, 2016Inflammation of the skin is found after various external stimuli, e.g., UV radiation, allergen uptake, microbial challenge, or contact with irritants, as well as due to intrinsic, not always well-defined, stimuli, e.g., in autoimmune responses. Often, it is also triggered by a combination of both.
Katja, Bäsler, Johanna M, Brandner
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Keeping skin inflammation local
Nature Immunology, 2017Silencing of the chromatin remodeler Mi-2β in keratinocytes triggers local skin inflammation. Regulatory T cells activated by the cytokine TSLP control the shift from local skin inflammation to systemic lethal disease.
Lucia, Pattarini, Vassili, Soumelis
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Leukotrienes as mediators of skin inflammation
British Journal of Dermatology, 2006Leukotrienes (LTs) derived from the 5-lipoxygenase pathways of arachidonic acid metabolism, are a new group of biologically active mediators. LTC4, LTD4 and LTE4 are considered collectively to account for the activity of slow reacting substance of anaphylaxis (SRS-A). They have potent smooth muscle contracting activity (Drazen et al., 1980; Holme et al.
A W, Ford-Hutchinson, A, Rackman
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The Role of Inflammation in Skin Cancer
2014Cancer is an environmental disease and skin cancer (melanoma and non-melanoma) is the most common of all cancers. Epidemiological and experimental evidence suggest "chronic inflammation" to be one of the hallmarks in solar ultraviolet radiation and several other environmental agent-mediated skin cancers.
Girish B, Maru +3 more
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Keratinocytes in skin inflammation
Expert Review of Dermatology, 2006Substantial evidence during the past years has indicated that keratinocytes play an active role in the generation and expression of protective immune responses and immunopathological reactions in the skin. In resting keratinocytes, immune mediators are barely detectable.
Pastore S +3 more
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Experimental models of skin inflammation
Clinical & Experimental Allergy, 1999The skin is the most accessible organ of the body in which to view the inflammatory process and its pharmacological modulation. However, there are relatively few studies in which the response of the dermal vasculature to inflammatory stimuli has been assessed quantitatively or the chemical mediators of the response measured directly.
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Epithelial Cell Death and Inflammation in Skin
2015The presence of dying cells in inflamed tissues has been recognized since many years, but until recently cell death was considered primarily a consequence of inflammation. Recent data in mouse models suggest that cell death could provide a potent trigger of inflammation.
Kumari, Snehlata, Pasparakis, Manolis
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Swine as a model of skin inflammation
Inflammation, 1993A predictive animal model of skin inflammation is needed for the development of potential therapeutic agents. The existing models of inflammation rely on animals whose skin physiology or biochemistry differs significantly from human. The objective of this investigation was to evaluate the swine as a potential model of inflammation, because its skin has
X, Nair +5 more
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Auto-inflammation and the Skin
2018Inflammation is a complex response of tissues to harmful influences. These can be trauma, pathogens or irritants [1]. This mechanism is in principle beneficial and aims to remove problematic stimuli from the body, with the goal of restoring tissue homeostasis.
Ramtin Lichtenberger +3 more
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Differential effects of skin nerves on allergic skin inflammation
Allergy, 2009Allergic skin disorders can be affected by neurogenic signals, e.g. atopic dermatitis and urticaria are often reported to be exacerbated by stress. In support of this view, we have recently shown that sensory nerves and neuropeptides in murine skin contribute significantly to the development of allergic inflammatory responses (1).
R, Vieira dos Santos +4 more
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