Results 261 to 270 of about 876,258 (302)

IL-18 and skin inflammation

Autoimmunity Reviews, 2009
IL-18 belongs to the IL-1 family of cytokines and has recently regained interest in the context of inflammasome activation. The inflammasome dependent caspase 1 cleaves pro-IL-18 into the active form - similar to what is known for IL-1ss. Still, the action and importance of IL-18 are not completely understood.
Miriam, Wittmann, Andrew, Macdonald, Julius, Renne   +2 more
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Keratinocytes in skin inflammation

Expert Review of Dermatology, 2006
Substantial evidence during the past years has indicated that keratinocytes play an active role in the generation and expression of protective immune responses and immunopathological reactions in the skin. In resting keratinocytes, immune mediators are barely detectable.
Pastore S, Mascia F, Mariani V, GIROLOMONI, Giampiero   +3 more
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Experimental models of skin inflammation

Clinical & Experimental Allergy, 1999
The skin is the most accessible organ of the body in which to view the inflammatory process and its pharmacological modulation. However, there are relatively few studies in which the response of the dermal vasculature to inflammatory stimuli has been assessed quantitatively or the chemical mediators of the response measured directly.
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Junctions and Inflammation in the Skin

Cell Communication & Adhesion, 2014
The skin forms a life-sustaining barrier between the organism and physical environment. The physical barrier of skin is mainly localized in the stratum corneum (SC); however, nucleated epidermis also contributes to the barrier through tight, gap, and adherens junctions (AJs), as well as through desmosomes and cytoskeletal elements.
Agnieszka, Kobielak, Keerthi, Boddupally
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MicroRNAs: novel regulators in skin inflammation

Clinical and Experimental Dermatology, 2008
Compelling evidence indicates that microRNAs (miRNAs), short, non-protein coding RNAs, are critical for the development and survival of multicellular organisms. Recently, miRNAs were implicated in the pathogenesis of psoriasis and atopic eczema (AE), the two most common chronic inflammatory disorders in skin.
E, Sonkoly, M, Ståhle, A, Pivarcsi
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Capillary Microscopy in Induced Skin Inflammation

Archives of Dermatology, 1963
Inflammatory changes were produced in the human skin by means of: (1) physical trauma (cellophane tape stripping); (2) application of a primary irritant (phenol); (3) sensitization (2,4,dinitrochlorobenzene). An ointment containing nicotinic acid was used as a vasodilator substance.
Y, RAPP, F S, GLICKMAN, L, FRANK
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Nanomedicine Strategies for Targeting Skin Inflammation

Nanomedicine, 2014
Topical treatment of skin diseases is an attractive strategy as it receives high acceptance from patients, resulting in higher compliance and therapeutic outcomes. Recently, the use of variable nanocarriers for dermal application has been widely explored, as they offer several advantages compared with conventional topical preparations, including higher
Mona Ma, Abdel-Mottaleb, Celine, Try, Yann, Pellequer, Alf, Lamprecht   +3 more
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Topical ivermectin improves allergic skin inflammation

Allergy, 2017
AbstractBackgroundIvermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested thatIVMcould also have anti‐inflammatory properties.MethodsHere, we investigated the activity ofIVMin a murine model of atopic dermatitis (AD) induced by repeated exposure to the allergenDermatophagoides ...
Ventre, Erwan, Rozières, Aurore, Lenief, Vanina, Albert, Floriane, Rossio, P., Laoubi, Léo, Dombrowicz, D., Staels, B., Ulmann, Lauriane, Julia, V., Vial, E., Jomard, A., Hacini-Rachinel, F., Nicolas, Jean-François, Vocanson, Marc   +14 more
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Leukotrienes as mediators of skin inflammation

British Journal of Dermatology, 2006
Leukotrienes (LTs) derived from the 5-lipoxygenase pathways of arachidonic acid metabolism, are a new group of biologically active mediators. LTC4, LTD4 and LTE4 are considered collectively to account for the activity of slow reacting substance of anaphylaxis (SRS-A). They have potent smooth muscle contracting activity (Drazen et al., 1980; Holme et al.
A W, Ford-Hutchinson, A, Rackman
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Pentoxifylline and skin inflammation.

Clinical and experimental dermatology, 1999
Cyclic nucleotide phosphodiesterase inhibitors, such as pentoxifylline, have been shown to beneficially influence a large number of inflammatory skin diseases. The biological effects of pentoxifylline on the production of proinflammatory cytokines, leukocyte-endothelial cell adhesion, chemokines and leukocyte-keratinocyte adhesion in skin inflammation ...
I, Bruynzeel, T J, Stoof, R, Willemze
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