Results 241 to 250 of about 1,153,145 (290)
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Irritants and Skin Barrier Function
2016The barrier response to irritant challenge involves complex biologic events and can be modulated by various environmental, exposure and host-related factors. Irritant damage to the epidermal barrier elicits a cascade of homeostatic or pathologic responses that could be investigated by both in vitro and in vivo methods providing different information at
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Skin irritation and sensitization
Journal of Controlled Release, 1991In the last years transdermal drug delivery systems have been used extensively. One of the major limitations of this application system is whether an irritation or an allergic reaction of the skin takes place [ 1,2]. In both skin conditions, inflammation of the skin is the underlying cause.
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Cardanol, a Skin Irritant in Pink Pepper
Planta Medica, 1983Cardanol 15:1 was isolated and characterized from the fruit of SCHINUS TEREBINTHIFOLIUS R ADDI, commonly known as the spice Pink Pepper. It is present in a content of 0.03 per cent in the fruit from Reunion and of 0.05 per cent in those of Florida. A skin test showed that the substance had a strong skin irritating effect after a relatively long latency
E, Stahl, K, Keller, C, Blinn
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International Journal of Dermatology, 1991
M M, Bason, V, Gordon, H I, Maibach
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M M, Bason, V, Gordon, H I, Maibach
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Assessment of skin irritancy: measurement of skin fold thickness
Contact Dermatitis, 1983It is desirable to use more objective methods than visual scoring for the assessment of skin irritancy reactions. The edema, or fluid accumulation in the exposed skin sites, can be accurately measured by a caliper and this alternative method of assessment is evaluated from different aspects.
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The validation of in vitro methods for skin irritation
Toxicology Letters, 2004Several alternative in vitro methods for identifying skin irritants have been developed in the last 10 years, the most promising of which use either reconstituted human skin models or animal (e.g. pig or mouse) skin organ cultures. In 1998, the European Centre for the Validation of Alternative Methods (ECVAM) commissioned a pre-validation study of five
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DNCB — Reactivity and Skin Irritation
New England Journal of Medicine, 1973Bleumink, E., Nater, J. P., The, H.
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