Results 31 to 40 of about 938,782 (286)

ACUTE DERMAL IRRITATION AND SKIN SENSITIZATION STUDY OF MESOPOROUS ANTIBACTERIAL BIOACTIVE GLASS MICROSPHERE IMPREGNATED SURGICAL COTTON GAUZE DRESSING MATERIAL ON RABBITS AND GUINEA PIGS [PDF]

Exploratory Animal and Medical Research
: A study was undertaken to evaluate the skin sensitization and acute dermal irritation of Mesoporous antibacterial bioactive glass microsphere impregnated non-woven surgical cotton gauze (MABGmscg) dressings on shaved rabbits and guinea pigs. This study
Debolina Dattaray, Payal Roy, Raja L, Jui Chakraborty, Tapan Kumar Mandal   +4 more
doaj   +1 more source

Evaluation of Two Novel Hydantoin Derivatives Using Reconstructed Human Skin Model Episkin^TM: Perspectives for Application as Potential Sunscreen Agents

Molecules, 2022
This study aimed to assess two novel 5-arylideneimidazolidine-2,4-dione (hydantoin) derivatives (JH3 and JH10) demonstrating photoprotective activity using the reconstructed human skin model EpiskinTM. The skin permeability, irritation, and phototoxicity
Karolina Słoczyńska, Justyna Popiół, Agnieszka Gunia-Krzyżak, Paulina Koczurkiewicz-Adamczyk, Paweł Żmudzki, Elżbieta Pękala   +5 more
doaj   +1 more source

Skin Tests of a Novel Nicotine Patch, PHK-301p, in Healthy Male Volunteers: Phase I, Placebo-Controlled Study

Journal of Pharmacological Sciences, 2006
Major local adverse reactions in the nicotine patches are skin reactions. To assess the skin reaction of PHK-301p, a newly developed nicotine patch, we conducted a phase I study that consisted of 2 parts: a skin irritation test (48-h closed patch test ...
Shin Irie, Hiroshi Tsukikawa, Toshitaka Nabeshima, Makiko Usami, Tadaaki Karino, Shuichi Komatsu, Moriaki Akasaki   +6 more
doaj   +1 more source

Irritation Test of Cream Preparations Made from Purple Cabbage Extract Against Healthy Skin Using The Path Test Method

Jurnal Info Kesehatan
Testing for skin irritation caused by new substances is a critical component of safety evaluation procedures. Pharmaceutical formulations and active ingredients intended for topical application have the potential to cause skin irritation, necessitating ...
Deswani Deswani, Sri Djuwitaningsih, Harpolia Cartika, Paul Malau   +3 more
doaj   +1 more source

Topical minocycline foam 4%: Results of four phase 1 studies evaluating the potential for phototoxicity, photoallergy, sensitization, and cumulative irritation

Journal of Immunotoxicology, 2019
FMX101 4% contains 4% micronized minocycline (as an HCl) formulated in a lipophilic foam vehicle for topical administration. FMX101 4% has been shown to be an effective and well-tolerated treatment for moderate-to-severe acne in three Phase 3 pivotal ...
Jonathan Dosik, Herman Ellman, Iain Stuart   +2 more
doaj   +1 more source

In Vivo Irritation and Sensitization Assessment of Cypermethrin, Pymetrozine, and Indoxacarb–Emamectin Benzoate Combination in Test Animals

Journal of Toxicology
Insecticides are widely used to protect agricultural and plantation products from pests and plant-disrupting organisms. Prior to market distribution, pesticide-containing products must undergo safety evaluations, including assessments of potential skin ...
Wahyu Daradjat Natawigena, Kirana Fayruz Swarga, Gloria Mahayarni Lastiar Sitinjak, Muhammad Ilfadry Rifasta, Agus Susanto, Gofarana Wilar, Cecep Suhandi   +6 more
doaj   +1 more source

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino, Lavanya Muthukumar, Evan L. Reynolds, Peter Todd, Sinem Ovunc, Sheng Chih Jin, Zitian Tang, Simone Thomas, PNRR Study Group, Ahmet Höke, Brian C. Callaghan, Sarah Berth, Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Hristelina Ilieva, Thomas Lloyd, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Bipasha Mukherjee‐Clavin, Lyle Ostrow, Michael Polydefkis, Ricardo Roda, Charlotte Sumner   +25 more
wiley   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Toxicity evaluation of metsulfuron-methyl, nicosulfuron, and methoxyfenozide as pesticides in Indonesia

Open Agriculture
Pesticides are substances widely used to control or eliminate pests, including weeds, insects, and other harmful organisms. Agricultural pesticides, in particular, must meet specific safety and quality standards before being marketed.
Natawigena Wahyu Daradjat, Rifasta Muhammad Ilfadry, Susanto Agus, Wilar Gofarana, Suhandi Cecep   +4 more
doaj   +1 more source

Human Skin Permeation of Ethoxy- and Propoxypropanol Commonly Found in Water-Based Products

Toxics
Some propylene glycol ethers (PGEs) have been associated with reproductive toxicity. Ethoxypropanol (PGEE) and propoxypropanol (PGPE) are two common PGEs found in many commercial products.
Hélène P. De Luca, Jennifer Pache, Philipp Spring, Aurélie Berthet, Nancy B. Hopf   +4 more
doaj   +1 more source