Results 41 to 50 of about 556 (209)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Skin lesion segmentation: U-Nets versus clustering [PDF]
2017 IEEE Symposium Series on Computational Intelligence (SSCI), 2017 To appear in proceedings of The IEEE Symposium Series on Computational Intelligence (IEEE SSCI 2017), Honolulu, Hawaii, USA, Nov.
Bill S. Lin +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Automated skin lesion segmentation of dermoscopic images using GrabCut and k‐means algorithms
IET Computer Vision, 2018 Skin cancer is the most common type of cancer in the world and the incidents of skin cancer have been rising over the past decade. Even with a dermoscopic imaging system, which magnifies the lesion region, detecting and classifying skin lesions by visual
Seetharani Murugaiyan Jaisakthi +2 more
doaj +1 more source
Dense-Residual Network With Adversarial Learning for Skin Lesion Segmentation
IEEE Access, 2019 Skin lesion segmentation in dermoscopic images is a challenging task in the domain of medical images analysis because of the irregular and blurring edges of the lesion and the presence of various artifacts.
Wenli Tu +3 more
doaj +1 more source
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
MUCM-Net: a Mamba powered UCM-Net for skin lesion segmentation [PDF]
Exploration of MedicineAim: Skin lesion segmentation is critical for early skin cancer detection. Challenges in automatic segmentation from dermoscopic images include variations in color, texture, and artifacts of indistinct lesion boundaries.
Chunyu Yuan +2 more
doaj +1 more source
Skin Lesion Segmentation by U-Net with Adaptive Skip Connection and Structural Awareness
Applied Sciences, 2021 Skin lesion segmentation is one of the pivotal stages in the diagnosis of melanoma. Many methods have been proposed but, to date, this is still a challenging task.
Tran-Dac-Thinh Phan +3 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu +7 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos +2 more
wiley +1 more source