Results 111 to 120 of about 62,571 (334)

Cold Atmospheric Plasma Selectively Disrupts Breast Cancer Growth in a Bioprinted 3D Tumor‐Stroma Co‐Culture Model

Advanced Healthcare Materials, EarlyView.
This research introduces a cold plasma‐based platform for treating breast cancer bone metastases. Using a novel bioprinted 3D tumor‐stroma model, it highlights the selective antitumor effects of plasma‐generated reactive species. The platform aims to advance non‐invasive therapeutic strategies, offering potential clinical applications in controlling ...
Laura M. Bouret, Jean‐Baptiste Billeau, Michael H. Weber, Derek H. Rosenzweig, Stephan Reuter   +4 more
wiley   +1 more source

Permeation Pathway of Macromolecules and Nanospheres through Skin

Biological and Pharmaceutical Bulletin, 2010
The permeation pathway of macromolecules and nanospheres through skin was evaluated using fluorescent isothiocyanate (FITC)-dextran (average MW, 4 kDa) (FD-4) and nanospheres (500 nm in diameter) in hairless rat abdominal skin and porcine ear skin as well as a three-dimensional cultured human skin model (cultured skin model).
Yoshihiro Tokudome, Fumie Hashimoto, Yoshiaki Ikarashi, Kenji Sugibayashi, Hiroaki Todo, Eriko Kimura, Hirotaka Yasuno   +6 more
openaire   +4 more sources

Structural Motifs in Soft Fibrous Tissues: Revealing Structure‐Mechanics Relationships in Deformation and Tear Resistance for Biomimetic Material Design

Advanced Healthcare Materials, EarlyView.
This review explores how soft fibrous tissues achieve their remarkable mechanical behavior through recurring structural motifs across multiple length scales. It highlights key advances in mimicking these features using fiber‐reinforced hydrogels and hierarchical composites, offering insights into mechanical compatibility, flaw tolerance, and tear ...
Mirit Sharabi
wiley   +1 more source

Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation

Pharmaceutics
Transdermal drug delivery (TDD) is an increasingly important non-invasive method for administering active pharmaceutical ingredients (APIs) through the skin barrier, offering advantages such as improved therapeutic efficacy and reduced systemic side ...
Elena O. Bakhrushina, Marina M. Shumkova, Yana V. Avdonina, Arsen A. Ananian, Mina Babazadeh, Ghazaleh Pouya, Viktoria V. Grikh, Irina M. Zubareva, Svetlana I. Kosenkova, Ivan I. Krasnyuk, Ivan I. Krasnyuk   +10 more
doaj   +1 more source

Učinci adheziva osjetljivih na tlak i kemijskih promotora na permeaciju fentanila kroz kožu štakora [PDF]

, 2006
Drug-in-adhesive patches (DIAPs) of fentanyl were formulated using various pressure sensitive adhesives (PSAs) and various chemical permeation enhancers (CPEs).
AMIR MEHDIZADEH, MOHAMMAD HOSSAIN GHAHREMANI, MOHAMMAD REZA ROUINI, TAYEBEH TOLIYAT   +3 more
core   +1 more source

Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery

Advanced Healthcare Materials, EarlyView.
This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis, Joanne Heade, Cristiana Cunha, Marco van de Weert, Lasse Saaby, Stine Rønholt, Hanne Mørck Nielsen   +6 more
wiley   +1 more source

Meloxicam transdermal delivery: effect of eutectic point on the rate and extent of skin permeation [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective(s):Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for ...
Soliman Mohammadi-Samani, Gholamhossein Yousefi, Farhad Mohammadi, Fatemeh Ahmadi   +3 more
doaj  

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Advanced Healthcare Materials, EarlyView.
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed   +6 more
wiley   +1 more source

Drug-Phospholipid Complex-loaded Matrix Film Formulation for the Enhanced Transdermal Delivery of Quercetin [PDF]

, 2018
A novel quercetin-phospholipid-complex(QPLC)-loaded matrix film for improved transdermal delivery of quercetin was developed. The QPLC formulation, prepared using a solvent-evaporation method, was optimized using a central-composite design. The optimized
Anand, Sridhar, Dave, Vivek S., Patil, Arun T., Telange, Darshan R., Umekar, Milind J., Wavare, Kuldeep D.   +5 more
core   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source