Results 81 to 90 of about 3,452,528 (293)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Low maternal care enhances the skin barrier resistance of offspring in mice.

PLoS ONE, 2019
Deprivation of maternal care via lack of somatosensory input causes offspring to experience adverse consequences, especially in the central nervous system.
Takashi Sakamoto, Yukino Ishio, Yuiko Ishida, Kazutaka Mogi, Takefumi Kikusui   +4 more
doaj   +1 more source

Bacterial contamination of human skin allografts and antimicrobial resistance: a skin bank problem

BMC Microbiology, 2018
Background Bacterial contamination remains the major problem in skin banks, even after antimicrobial treatment, and results in high rates of tissue discarding.
Karine Lena Meneghetti, Micaela do Canto Canabarro, Letícia Muner Otton, Thaís dos Santos Hain, Mercedes Passos Geimba, Gertrudes Corção   +5 more
doaj   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Effect of Nitric Oxide on Noradrenergic Function and Skin Electric Resistance of Acupoints and Meridians

针刺研究, 2008
Most acupuncture points correspond to low skin-resistance points(LSRP) on the body surface along the meridians.We did three experiments which conformed that the skin nitric oxide(NO) concentration and expression of neuronal nitric oxide synthesis(nNOS ...
LIANG Yuan, MA Sheng-xing1, CHEN Jia-xu
doaj  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer
Background Immunotherapy that includes immune checkpoint inhibitors (ICI) is a revolutionary arm of the treatment of skin cancers like melanoma, basal cell carcinoma, and squamous cell carcinoma.
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
doaj   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

How To Order SkinCell Pro Skin Tag

, 2021
SkinCell Pro Skin Tag Of all of the products on the market today, I don't really think any of them can perform miracles with aging skin. They can fill in some, tighten some and moisturize a lot. Aging is inevitable.
SkinCell Pro Skin Tag
core   +1 more source

Effect of surface spinal stimulation on autonomic nervous system in the patients with spinal cord injury

Archives of Medicine and Health Sciences, 2014
Background: The Autonomic Nervous System (ANS) plays a key role in the regulation of many physiological processes, mediated by supraspinal control from centers in the central nervous system.
Bhavkiran Kaur, Narkeesh Arumugam
doaj   +1 more source