Results 61 to 70 of about 3,452,528 (293)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Skin blood perfusion and oxygenation colour affect perceived human health [PDF]

, 2009
I Stephen was funded by a BBSRC Studentship.Skin blood perfusion and oxygenation depends upon cardiovascular, hormonal and circulatory health in humans and provides socio-sexual signals of underlying physiology, dominance and reproductive status in some ...
Stephen, ID, David I. Perrett, Miriam Law Smith, David I Perrett, Stephen, Ian David, Perrett, DI, Ian D. Stephen, Stephen Ian D., Law Smith, M, Perrett David I., Coetzee Vinet, Vinet Coetzee, Ian D Stephen, Law Smith Miriam, Coetzee, Vinet, Law Smith, Miriam Jane, Coetzee, V, Perrett, David Ian   +17 more
core   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050 [PDF]

Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed ...
GBD, 2021 Antimicrobial Resistance Collaborators, GBD 2021 Antimicrobial Resistance Collaborators   +1 more
core   +1 more source

Development and Verification of Microclimate Control System for Enhanced Driver Comfort and Safety Based on Skin Resistance Measurements

Acta Technologica Agriculturae
This study deals with the design and construction of a device that enhances driver comfort and safety by automatically adjusting the microclimate in the vehicle cabin based on real-time skin resistance measurements.
Kollárik Rastislav, Vitázek Ivan, Janča Jan, Jukić Željko   +3 more
doaj   +1 more source

Xylose Improves Antibiotic Activity of Chloramphenicol and Tetracycline against K. pneumoniae and A. baumannii in a Murine Model of Skin Infection

Canadian Journal of Infectious Diseases and Medical Microbiology, 2018
Increased resistance to antimicrobials in clinically important bacteria has been widely reported. The major mechanism causing multidrug resistance (MDR) is mediated by efflux pumps, proteins located in the cytoplasmic membrane to exclude antimicrobial ...
Alejandro A. Hidalgo, Ángel J. Arias, Juan A. Fuentes, Patricia García, Guido C. Mora, Nicolás A. Villagra   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Enhanced chlorhexidine skin penetration with eucalyptus oil [PDF]

, 2010
Background Chlorhexidine digluconate (CHG) is a widely used skin antiseptic, however it poorly penetrates the skin, limiting its efficacy against microorganisms residing beneath the surface layers of skin. The aim of the current study was to improve the
Conway, Barbara R, Anthony C Hilton, Elliott Tom SJ, Lambert Peter A, Hilton, Anthony C, Karpanen Tarja J, Peter A Lambert, Tarja J Karpanen, Hilton Anthony C, Tony Worthington, Worthington, Tony, Karpanen, Tarja J., Elliott, T.S.J., Lambert, P.A., Karpanen, Tarja J, Worthington, T., Tom SJ Elliott, Hilton, A.C., Elliott, Tom S J, Conway Barbara R, Hilton, Anthony C., Worthington Tony, Conway, Barbara R., Karpanen, T.J., Lambert, Peter A, Lambert, Peter A., Barbara R Conway   +26 more
core   +2 more sources

Gene Expression Response to Sea Lice in Atlantic Salmon Skin: RNA Sequencing Comparison Between Resistant and Susceptible Animals

Frontiers in Genetics, 2018
Sea lice are parasitic copepods that cause large economic losses to salmon aquaculture worldwide. Frequent chemotherapeutic treatments are typically required to control this parasite, and alternative measures such as breeding for improved host resistance
Diego Robledo, Alejandro P. Gutiérrez, Agustín Barría, José M. Yáñez, José M. Yáñez, Ross D. Houston   +5 more
doaj   +1 more source