Results 51 to 60 of about 1,225,162 (311)

Professional soccer and skin temperature [PDF]

open access: yesJournal of the European Academy of Dermatology and Venereology, 2018
Linked article: This is a commentary on D. Rodriguez‐Sanz et al., pp. 2020–2024 in this issue.
openaire   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Impact of Physiological Signals Acquisition in the Emotional Support Provided in Learning Scenarios

open access: yesSensors, 2019
Physiological sensors can be used to detect changes in the emotional state of users with affective computing. This has lately been applied in the educational domain, aimed to better support learners during the learning process.
R. Uria-Rivas   +4 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Examining Occupant-Comfort Responses to Indoor Humidity Ratio in Conventional and Vernacular Dwellings: A Rural Indian Case Study

open access: yesEnergies, 2023
Optimum indoor humidity is often associated with comfort and overall well-being. Occupant comfort is often evaluated with a focus on “thermal comfort” using the PMV (predicted mean vote), PDD (predicted percentage of dissatisfied), and adaptive thermal ...
Suchi Priyadarshani   +3 more
doaj   +1 more source

Temperature controller for a fluid cooled garment [PDF]

open access: yes, 1973
An automatic controller for controlling the inlet temperature of the coolant to a fluid cooled garment without requiring skin sensors is described.
Billingham, J.   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Roughness effects in turbulent forced convection [PDF]

open access: yes, 2018
We conducted direct numerical simulations (DNSs) of turbulent flow over three-dimensional sinusoidal roughness in a channel. A passive scalar is present in the flow with Prandtl number $Pr=0.7$, to study heat transfer by forced convection over this rough
Chung, D., Hutchins, N., MacDonald, M.
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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