Results 91 to 100 of about 2,229,109 (306)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ANALISIS KANDUNGAN ANTIOKSIDAN DAN KUALITAS SENSORI TEH KULIT BIJI KAKAO (Theobroma cacao) DENGAN PENAMBAHAN KAYU MANIS (Cinnamomum burmannii) [PDF]

Processing cocoa beans into chocolate products has a by-product in the form of cocoa husk. Cocoa husk has the potential to be processed into herbal tea. Cocoa husk herbal tea has a bland taste and a astringent mouthfeel.
Nurrahma, Ilmi Shofia
core  

Association between vitamin d deficiencies in sarcoidosis with disease activity, course of disease and stages of lung involvements [PDF]

, 2017
Background: Despite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency
Abedini, A, Adcock, IM, Kazempour-Dizaji, M, Kiani, A, Mirenayat, MS, Mortaz, E, Taghavi, K   +6 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Case Report: Mast cell anergy: absence of symptoms after accidental re-exposure to amoxicillin/clavulanic acid 3 days after anaphylaxis

Frontiers in Allergy
Empty mast cell syndrome, also named post anaphylaxis mast cell anergy (PAMA), is a temporary state of loss of mast cell responsiveness after a severe immediate hypersensitivity reaction.
Loris Guyénard, Loris Guyénard, Marie Tauber, Marie Tauber, Sophie Debord-Peguet, Sophie Debord-Peguet, Frédéric Berard, Frédéric Berard, Audrey Nosbaum, Audrey Nosbaum, Florence Hacard, Florence Hacard, Mariana Castells, Jean-François Nicolas, Jean-François Nicolas   +14 more
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

An Automatic Human Face Detection Method [PDF]

, 1999
This article contains a proposal for an automatic human face detection method, that tries to join several theories proposed by different authors. The method is based on detection of shape features (eye pairs) and skin color.
Peer, Peter, Solina, Franc
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Response to venom immunotherapy: Exploratory retrospective machine learning clustering analysis

Journal of Allergy and Clinical Immunology: Global
Background: Hymenoptera venom immunotherapy is an established treatment for severe allergic reactions, aiming to modulate the immune response and reduce allergen sensitivity. However, traditional methods such as skin tests and specific IgE quantification
Stefano Palazzo, MSc, PEng, Marcello Albanesi, MD, PhD, Mattia Cristallo, MD, Francesco Pugliese, MD, Nada Chaoul, MSc, PhD, Giulia Caffarella, Alessandro Cinquantasei, MSc, Cataldo Piarulli, Marco Cinquantasei, Marco Aprigliano, Roberto Caldelli, PEng, PhD, Claudio Loconsole, PEng, PhD, Silvio Tafuri, MD, PhD, Eustachio Nettis, MD, Attilio Di Girolamo, MD   +14 more
doaj   +1 more source