Results 101 to 110 of about 667,674 (262)

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Anaphylaxis due to midazolam administered before induction of general anesthesia: a case report

JA Clinical Reports
Background Anaphylaxis is an immediate allergic reaction. However, in some cases, there is a delay between the administration of the causative agent and the onset of anaphylaxis.
Ryosuke Funabiki, Tatsuo Horiuchi, Toshie Shiraishi, Masaki Orihara, Kazuhiro Nagumo, Shigeru Saito   +5 more
doaj   +1 more source

Skin prick test in milk allergic patients undergoing oral immunotherapy: Does the milk form used for skin tests matter? [PDF]

Front Allergy, 2022
Bukhari E, Gabrielli S, McCusker C, Upton J, Grunebaum E, Chan ES, Beaudette L, Langlois A, Torabi B, Lejtenyi D, Clarke AE, Ke D, Mazer BD, Ben-Shoshan M.   +13 more
europepmc   +1 more source

Intracutaneous Skin Tests and Serum IgE Levels Cannot Predict the Grade of Anaphylaxis in Patients with Insect Venom Allergies. [PDF]

J Asthma Allergy, 2022
Hollstein MM, Matzke SS, Lorbeer L, Forkel S, Fuchs T, Lex C, Buhl T.   +6 more
europepmc   +1 more source

Immunology of Skin Tests

Ear, Nose & Throat Journal, 1996
J R, Leipzig, R G, Slavin
openaire   +2 more sources

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Systemic reaction during intradermal skin tests with beta-lactams. [PDF]

BMJ Case Rep, 2021
Carvalho J, Oliveira G.
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Coronavirus disease 2019 messenger RNA vaccine skin tests and serum histamine levels in allergic reactions. [PDF]

Ann Allergy Asthma Immunol, 2022
Kohli-Pamnani A, Zapata K, Gibson T, Kwittken PL.   +3 more
europepmc   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source