Results 101 to 110 of about 1,376,553 (308)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Diagnostic Value of In Vitro Tests for Peanut Allergy in Children Without Clinical Exposure: A High-Specificity Rule-In Decision Pathway—Preliminary Findings from a Single-Center Study in Polish Children

Children
Background: Diagnosing peanut allergy (PA) in children without known exposure remains challenging due to the need to distinguish true clinical allergy from asymptomatic sensitization.
Julia Tworowska, Kinga Lis, Zbigniew Bartuzi, Aneta Krogulska   +3 more
doaj   +1 more source

Secondary bacterial infections of buruli ulcer lesions before and after chemotherapy with streptomycin and rifampicin [PDF]

, 2013
Buruli ulcer (BU), caused by Mycobacterium ulcerans is a chronic necrotizing skin disease. It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast bacilli.
AA Pahlevan, AB Wysocki, Albert Paintsil, AO Shittu, AO Shittu, AW Bauer, Benjamin Anku, Cynthia Kwakye-Maclean, D Yeboah-Manu, Dorothy Yeboah-Manu, E Coutanceau, E Coutanceau, E Mensah-Quainoo, Evelyn Owusu-Mireku, G Bori, Gerd Pluschke, Grace S. Kpeli, HC Gram, IG Schraibman, Isaac Lamptey, J Guarner, J Hayman, JP Heggers, K GjØdsbØl, K Twum-Danso, KM Dobos, KM George, KM George, Kobina Asan-Ampah, Kwabena Quenin-Fosu, L Katz, M Cruickshank, M Karas, Marie-Thérèse Ruf, MC Robson, Mercy Newman, NA Stotts, NS Levine, Pamela L. C. Small, PG Bowler, RC Daltery, S Adusumilli, S Etuaful, W Curreri, W Majewski, WA Nienhuis   +45 more
core   +3 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A Systematic Review on the Safety of <i>Mycobacterium tuberculosis</i>-Specific Antigen-Based Skin Tests for Tuberculosis Infection Compared With Tuberculin Skin Tests. [PDF]

Open Forum Infect Dis, 2023
Hamada Y, Kontsevaya I, Surkova E, Wang TT, Wan-Hsin L, Matveev A, Ziganshina LE, Denkinger CM, Korobitsyn A, Ismail N, Abubakar I, Rangaka MX.   +11 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Resonance testing of space shuttle thermoacoustic structural specimen [PDF]

The resonance testing of a structural specimen related to the space shuttle vehicle is described. The specimen consisted of a thin aluminum skin reinforced by hat-section stringers and supported by two ribs or bulkheads of corrugated web.
Abrahamson, A. L., Osinski, J.
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Skin Prick Tests in Patients with Chronic Urticaria

European Journal of Inflammation, 2005
Acute or chronic urticaria is not a common manifestation of systemic disease. However it affects 15% of the population at least once during their lives. The most common causes of urticaria are allergic.
G. Ilonidis, G. Anogianakis, E. K. Theofilogiannakos, M. Trakatelli, A. Anogeianaki, M. Trakatelli, D. Economidis   +6 more
doaj   +1 more source

Emergency in-flight egress opening for general aviation aircraft [PDF]

, 1980
An emergency in-flight egress system was installed in a light general aviation airplane. The airplane had no provision for egress on the left side.
Bement, L. J.
core   +2 more sources